SERP2_HUMAN
ID SERP2_HUMAN Reviewed; 65 AA.
AC Q8N6R1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Stress-associated endoplasmic reticulum protein 2;
DE AltName: Full=Ribosome-associated membrane protein RAMP4-2;
GN Name=SERP2; Synonyms=C13orf21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May interact with target proteins during translocation into
CC the lumen of the endoplasmic reticulum. May protect unfolded target
CC proteins against degradation and facilitate correct glycosylation
CC (Potential). {ECO:0000305}.
CC -!- INTERACTION:
CC Q8N6R1; Q5BKT4: ALG10; NbExp=3; IntAct=EBI-749270, EBI-13064220;
CC Q8N6R1; Q13520: AQP6; NbExp=3; IntAct=EBI-749270, EBI-13059134;
CC Q8N6R1; Q13323: BIK; NbExp=3; IntAct=EBI-749270, EBI-700794;
CC Q8N6R1; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-749270, EBI-11532900;
CC Q8N6R1; Q9HA82: CERS4; NbExp=3; IntAct=EBI-749270, EBI-2622997;
CC Q8N6R1; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-749270, EBI-1045797;
CC Q8N6R1; P49447: CYB561; NbExp=3; IntAct=EBI-749270, EBI-8646596;
CC Q8N6R1; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-749270, EBI-8637742;
CC Q8N6R1; Q15125: EBP; NbExp=3; IntAct=EBI-749270, EBI-3915253;
CC Q8N6R1; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-749270, EBI-18535450;
CC Q8N6R1; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-749270, EBI-781551;
CC Q8N6R1; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-749270, EBI-18938272;
CC Q8N6R1; P12318-2: FCGR2A; NbExp=3; IntAct=EBI-749270, EBI-17187481;
CC Q8N6R1; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-749270, EBI-12142257;
CC Q8N6R1; A2A2Y4: FRMD3; NbExp=3; IntAct=EBI-749270, EBI-6911547;
CC Q8N6R1; O00258: GET1; NbExp=3; IntAct=EBI-749270, EBI-18908258;
CC Q8N6R1; Q9NS71: GKN1; NbExp=3; IntAct=EBI-749270, EBI-3933251;
CC Q8N6R1; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-749270, EBI-13345167;
CC Q8N6R1; O15529: GPR42; NbExp=3; IntAct=EBI-749270, EBI-18076404;
CC Q8N6R1; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-749270, EBI-749265;
CC Q8N6R1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-749270, EBI-2820517;
CC Q8N6R1; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-749270, EBI-10329546;
CC Q8N6R1; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-749270, EBI-373355;
CC Q8N6R1; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-749270, EBI-3923617;
CC Q8N6R1; P15941-11: MUC1; NbExp=3; IntAct=EBI-749270, EBI-17263240;
CC Q8N6R1; O14524-2: NEMP1; NbExp=3; IntAct=EBI-749270, EBI-10969203;
CC Q8N6R1; P35372-10: OPRM1; NbExp=3; IntAct=EBI-749270, EBI-12807478;
CC Q8N6R1; O14684: PTGES; NbExp=3; IntAct=EBI-749270, EBI-11161398;
CC Q8N6R1; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-749270, EBI-10192441;
CC Q8N6R1; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-749270, EBI-18397230;
CC Q8N6R1; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-749270, EBI-17247926;
CC Q8N6R1; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-749270, EBI-18159983;
CC Q8N6R1; O14863: SLC30A4; NbExp=3; IntAct=EBI-749270, EBI-13918058;
CC Q8N6R1; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-749270, EBI-9978441;
CC Q8N6R1; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-749270, EBI-10314552;
CC Q8N6R1; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-749270, EBI-17498703;
CC Q8N6R1; P27105: STOM; NbExp=3; IntAct=EBI-749270, EBI-1211440;
CC Q8N6R1; Q16623: STX1A; NbExp=3; IntAct=EBI-749270, EBI-712466;
CC Q8N6R1; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-749270, EBI-6268651;
CC Q8N6R1; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-749270, EBI-13351685;
CC Q8N6R1; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-749270, EBI-6448756;
CC Q8N6R1; Q6PL24: TMED8; NbExp=3; IntAct=EBI-749270, EBI-11603430;
CC Q8N6R1; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-749270, EBI-2821497;
CC Q8N6R1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-749270, EBI-8638294;
CC Q8N6R1; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-749270, EBI-11724423;
CC Q8N6R1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-749270, EBI-10982110;
CC Q8N6R1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-749270, EBI-11742770;
CC Q8N6R1; Q9Y320: TMX2; NbExp=3; IntAct=EBI-749270, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
CC Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RAMP4 family. {ECO:0000305}.
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DR EMBL; BC029067; AAH29067.1; -; mRNA.
DR EMBL; AL138960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31965.1; -.
DR RefSeq; NP_001010897.1; NM_001010897.2.
DR RefSeq; NP_001333909.1; NM_001346980.1.
DR AlphaFoldDB; Q8N6R1; -.
DR SMR; Q8N6R1; -.
DR BioGRID; 132508; 59.
DR IntAct; Q8N6R1; 50.
DR STRING; 9606.ENSP00000368477; -.
DR iPTMnet; Q8N6R1; -.
DR PhosphoSitePlus; Q8N6R1; -.
DR BioMuta; SERP2; -.
DR DMDM; 74751068; -.
DR jPOST; Q8N6R1; -.
DR MassIVE; Q8N6R1; -.
DR PaxDb; Q8N6R1; -.
DR PeptideAtlas; Q8N6R1; -.
DR PRIDE; Q8N6R1; -.
DR ProteomicsDB; 72221; -.
DR TopDownProteomics; Q8N6R1; -.
DR Antibodypedia; 77372; 1 antibodies from 1 providers.
DR DNASU; 387923; -.
DR Ensembl; ENST00000379179.8; ENSP00000368477.3; ENSG00000151778.11.
DR GeneID; 387923; -.
DR KEGG; hsa:387923; -.
DR MANE-Select; ENST00000379179.8; ENSP00000368477.3; NM_001010897.3; NP_001010897.1.
DR UCSC; uc001uzj.3; human.
DR CTD; 387923; -.
DR DisGeNET; 387923; -.
DR GeneCards; SERP2; -.
DR HGNC; HGNC:20607; SERP2.
DR HPA; ENSG00000151778; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q8N6R1; -.
DR OpenTargets; ENSG00000151778; -.
DR PharmGKB; PA162402953; -.
DR VEuPathDB; HostDB:ENSG00000151778; -.
DR eggNOG; KOG3491; Eukaryota.
DR GeneTree; ENSGT00940000162467; -.
DR HOGENOM; CLU_160944_3_0_1; -.
DR InParanoid; Q8N6R1; -.
DR OMA; AFHKNIN; -.
DR PhylomeDB; Q8N6R1; -.
DR TreeFam; TF313229; -.
DR PathwayCommons; Q8N6R1; -.
DR SignaLink; Q8N6R1; -.
DR BioGRID-ORCS; 387923; 17 hits in 1071 CRISPR screens.
DR ChiTaRS; SERP2; human.
DR GenomeRNAi; 387923; -.
DR Pharos; Q8N6R1; Tdark.
DR PRO; PR:Q8N6R1; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8N6R1; protein.
DR Bgee; ENSG00000151778; Expressed in Brodmann (1909) area 9 and 128 other tissues.
DR ExpressionAtlas; Q8N6R1; baseline and differential.
DR Genevisible; Q8N6R1; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010580; ER_stress-assoc.
DR PANTHER; PTHR15601; PTHR15601; 1.
DR Pfam; PF06624; RAMP4; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..65
FT /note="Stress-associated endoplasmic reticulum protein 2"
FT /id="PRO_0000274799"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..65
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 65 AA; 7431 MW; 4CA89CEF04336C06 CRC64;
MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSAIFQIIQS
IRMGM
