SERP2_MOUSE
ID SERP2_MOUSE Reviewed; 65 AA.
AC Q6TAW2; Q497L0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Stress-associated endoplasmic reticulum protein 2;
DE AltName: Full=Ribosome-associated membrane protein RAMP4-2;
GN Name=Serp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Hartmann E.;
RT "Mouse RAMP4-2.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May interact with target proteins during translocation into
CC the lumen of the endoplasmic reticulum. May protect unfolded target
CC proteins against degradation and facilitate correct glycosylation
CC (Potential). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
CC Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6TAW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6TAW2-2; Sequence=VSP_022876, VSP_022877;
CC -!- SIMILARITY: Belongs to the RAMP4 family. {ECO:0000305}.
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DR EMBL; AY425619; AAR01199.1; -; mRNA.
DR EMBL; BC100483; AAI00484.1; -; mRNA.
DR EMBL; BC115492; AAI15493.1; -; mRNA.
DR CCDS; CCDS49546.1; -. [Q6TAW2-1]
DR RefSeq; NP_001153798.1; NM_001160326.1. [Q6TAW2-1]
DR AlphaFoldDB; Q6TAW2; -.
DR SMR; Q6TAW2; -.
DR STRING; 10090.ENSMUSP00000068508; -.
DR PhosphoSitePlus; Q6TAW2; -.
DR MaxQB; Q6TAW2; -.
DR PaxDb; Q6TAW2; -.
DR PRIDE; Q6TAW2; -.
DR ProteomicsDB; 256968; -. [Q6TAW2-1]
DR ProteomicsDB; 256969; -. [Q6TAW2-2]
DR Antibodypedia; 77372; 1 antibodies from 1 providers.
DR DNASU; 72661; -.
DR Ensembl; ENSMUST00000064517; ENSMUSP00000068508; ENSMUSG00000052584. [Q6TAW2-1]
DR Ensembl; ENSMUST00000227076; ENSMUSP00000154122; ENSMUSG00000052584. [Q6TAW2-2]
DR GeneID; 72661; -.
DR KEGG; mmu:72661; -.
DR UCSC; uc011zor.1; mouse. [Q6TAW2-1]
DR CTD; 387923; -.
DR MGI; MGI:1919911; Serp2.
DR VEuPathDB; HostDB:ENSMUSG00000052584; -.
DR eggNOG; KOG3491; Eukaryota.
DR GeneTree; ENSGT00940000162467; -.
DR HOGENOM; CLU_160944_3_0_1; -.
DR InParanoid; Q6TAW2; -.
DR OMA; KHPVGPI; -.
DR OrthoDB; 1605112at2759; -.
DR PhylomeDB; Q6TAW2; -.
DR TreeFam; TF313229; -.
DR BioGRID-ORCS; 72661; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q6TAW2; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q6TAW2; protein.
DR Bgee; ENSMUSG00000052584; Expressed in superior frontal gyrus and 93 other tissues.
DR ExpressionAtlas; Q6TAW2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010580; ER_stress-assoc.
DR PANTHER; PTHR15601; PTHR15601; 1.
DR Pfam; PF06624; RAMP4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..65
FT /note="Stress-associated endoplasmic reticulum protein 2"
FT /id="PRO_0000274800"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..65
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT VAR_SEQ 53
FT /note="A -> G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022876"
FT VAR_SEQ 54..65
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022877"
FT CONFLICT 24
FT /note="V -> L (in Ref. 1; AAR01199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 65 AA; 7431 MW; 4CA89CEF04336C06 CRC64;
MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSAIFQIIQS
IRMGM
