ID   SERP3_BOVIN             Reviewed;         400 AA.
AC   A6QQ92;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Serpin E3;
DE   Flags: Precursor;
GN   Name=SERPINE3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AAFC03087391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03012792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC149709; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001093829.1; NM_001100359.3.
DR   AlphaFoldDB; A6QQ92; -.
DR   SMR; A6QQ92; -.
DR   STRING; 9913.ENSBTAP00000006956; -.
DR   MEROPS; I04.972; -.
DR   PaxDb; A6QQ92; -.
DR   Ensembl; ENSBTAT00000006956; ENSBTAP00000006956; ENSBTAG00000005284.
DR   GeneID; 513955; -.
DR   KEGG; bta:513955; -.
DR   CTD; 647174; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005284; -.
DR   VGNC; VGNC:34477; SERPINE3.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000160941; -.
DR   HOGENOM; CLU_023330_0_4_1; -.
DR   InParanoid; A6QQ92; -.
DR   OMA; KGNCISY; -.
DR   OrthoDB; 1124079at2759; -.
DR   TreeFam; TF352620; -.
DR   ChiTaRS; SERPINE3; cattle.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000005284; Expressed in cardiac ventricle and 88 other tissues.
DR   ExpressionAtlas; A6QQ92; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR031172; Serpin_E3.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF129; PTHR11461:SF129; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..400
FT                   /note="Serpin E3"
FT                   /id="PRO_0000340683"
FT   SITE            365..366
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   400 AA;  43923 MW;  66009E49EE4E9D82 CRC64;
     MQSLLLALLL LPVCSPGGAS NLHEDLTLLR TDLALRLYRS VAAAGNQTNL VLSPAGAFIP
     LELLQFGARG NTGRQLAQAL GYTVHDPKVR EWLQTVYAVL PSTNPGAKLE LACTLYVQTG
     TPLAPCFVEQ VSRWANSSLE LANFREPNST AMLANGWGPR QTAGDEPVGS AWERGGGAES
     AQLVLVSTVS FQSAWRHQFS SDTQLLPFTC AQGLTLEVPM MYQMAEVNFG QFQDPAGHQV
     GVLELPYLGN VASLLLVLPR DRDTPLSHIE PHLTASLLHA WTASLKRARM EVFLPRFRIQ
     NHFDLKNILY SWGVIDLFDP LRANLKGISG QDGFYVSEAI HKAKIEVSEE GTKASAATAL
     LLLKRSRIPI FKADRPFIFF LREPNTAFVF SIGRVLNPLH