ID   SERP3_HUMAN             Reviewed;         424 AA.
AC   A8MV23; B1V8P3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Serpin E3;
DE   Flags: Precursor;
GN   Name=SERPINE3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Smolyar A.;
RT   "Polynucleotides encoding nexin-related serine protease inhibitor.";
RL   Patent number WO03046006, 05-JUN-2003.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Bentele C., Ragg H.;
RT   "Identification and characterization of a novel human serpin.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8MV23-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8MV23-2; Sequence=VSP_037586;
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AX772926; CAE06272.1; -; mRNA.
DR   EMBL; AM402969; CAL47031.1; -; mRNA.
DR   EMBL; AL137780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471075; EAX08871.1; -; Genomic_DNA.
DR   CCDS; CCDS53870.1; -. [A8MV23-1]
DR   RefSeq; NP_001094790.1; NM_001101320.1. [A8MV23-1]
DR   AlphaFoldDB; A8MV23; -.
DR   SMR; A8MV23; -.
DR   STRING; 9606.ENSP00000428316; -.
DR   MEROPS; I04.972; -.
DR   GlyGen; A8MV23; 1 site.
DR   iPTMnet; A8MV23; -.
DR   PhosphoSitePlus; A8MV23; -.
DR   BioMuta; SERPINE3; -.
DR   MassIVE; A8MV23; -.
DR   PaxDb; A8MV23; -.
DR   PeptideAtlas; A8MV23; -.
DR   PRIDE; A8MV23; -.
DR   ProteomicsDB; 2143; -. [A8MV23-1]
DR   ProteomicsDB; 2144; -. [A8MV23-2]
DR   TopDownProteomics; A8MV23-1; -. [A8MV23-1]
DR   Antibodypedia; 63264; 9 antibodies from 5 providers.
DR   DNASU; 647174; -.
DR   Ensembl; ENST00000400389.5; ENSP00000441468.1; ENSG00000253309.7. [A8MV23-2]
DR   Ensembl; ENST00000521255.5; ENSP00000428316.1; ENSG00000253309.7. [A8MV23-1]
DR   Ensembl; ENST00000524365.5; ENSP00000430755.1; ENSG00000253309.7. [A8MV23-2]
DR   Ensembl; ENST00000681248.1; ENSP00000506411.1; ENSG00000253309.7. [A8MV23-2]
DR   GeneID; 647174; -.
DR   KEGG; hsa:647174; -.
DR   MANE-Select; ENST00000681248.1; ENSP00000506411.1; NM_001386375.1; NP_001373304.1. [A8MV23-2]
DR   UCSC; uc001vfh.3; human. [A8MV23-1]
DR   CTD; 647174; -.
DR   GeneCards; SERPINE3; -.
DR   HGNC; HGNC:24774; SERPINE3.
DR   HPA; ENSG00000253309; Tissue enhanced (brain, pancreas, retina).
DR   neXtProt; NX_A8MV23; -.
DR   OpenTargets; ENSG00000253309; -.
DR   PharmGKB; PA164725650; -.
DR   VEuPathDB; HostDB:ENSG00000253309; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000160941; -.
DR   HOGENOM; CLU_023330_0_4_1; -.
DR   InParanoid; A8MV23; -.
DR   OMA; KGNCISY; -.
DR   OrthoDB; 1124079at2759; -.
DR   PhylomeDB; A8MV23; -.
DR   TreeFam; TF352620; -.
DR   PathwayCommons; A8MV23; -.
DR   BioGRID-ORCS; 647174; 5 hits in 1062 CRISPR screens.
DR   ChiTaRS; SERPINE3; human.
DR   GenomeRNAi; 647174; -.
DR   Pharos; A8MV23; Tdark.
DR   PRO; PR:A8MV23; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; A8MV23; protein.
DR   Bgee; ENSG00000253309; Expressed in cerebellar hemisphere and 89 other tissues.
DR   ExpressionAtlas; A8MV23; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR031172; Serpin_E3.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF129; PTHR11461:SF129; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..424
FT                   /note="Serpin E3"
FT                   /id="PRO_0000340684"
FT   REGION          143..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..161
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            369..370
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         392..424
FT                   /note="ITVFFDRIQIIYQCLSSNKGSFVHYPLKNKHSF -> FVFSIGRVSNPLD
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_037586"
FT   VARIANT         143
FT                   /note="D -> N (in dbSNP:rs17790811)"
FT                   /id="VAR_044021"
SQ   SEQUENCE   424 AA;  46963 MW;  5B28DBB3317B4B1B CRC64;
     MPPFLITLFL FHSCCLRANG HLREGMTLLK TEFALHLYQS VAACRNETNF VISPAGVSLP
     LEILQFGAEG STGQQLADAL GYTVHDKRVK DFLHAVYATL PTSSQGTEME LACSLFVQVG
     TPLSPCFVEH VSWWANSSLE PADLSEPNST AIQTSEGASR ETAGGGPSEG PGGWPWEQVS
     AAFAQLVLVS TMSFQGTWRK RFSSTDTQIL PFTCAYGLVL QVPMMHQTTE VNYGQFQDTA
     GHQVGVLELP YLGSAVSLFL VLPRDKDTPL SHIEPHLTAS TIHLWTTSLR RARMDVFLPR
     FRIQNQFNLK SILNSWGVTD LFDPLKANLK GISGQDGFYV SEAIHKAKIE VLEEGTKASG
     ATALLLLKRS RIPIFKADRP FIYFLREPNT GITVFFDRIQ IIYQCLSSNK GSFVHYPLKN
     KHSF