SESD1_DANRE
ID SESD1_DANRE Reviewed; 714 AA.
AC Q7SX85; A4IG23; Q7ZZ43; Q8AW09;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=SEC14 domain and spectrin repeat-containing protein 1;
DE AltName: Full=Protein Solo;
GN Name=sestd1; Synonyms=sol, solo; ORFNames=si:dz106a20.1, si:dz42h5.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=AB; TISSUE=Embryo;
RX PubMed=12837271; DOI=10.1016/s0888-7543(03)00071-5;
RA Sato T., Mishina M.;
RT "Representational difference analysis, high-resolution physical mapping,
RT and transcript identification of the zebrafish genomic region for a motor
RT behavior.";
RL Genomics 82:218-229(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=WIK;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as the primary docking protein directing membrane
CC turnover and assembly of the transient receptor potential channels
CC trpc4 and trpc5. Binds phospholipids (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7SX85-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7SX85-2; Sequence=VSP_035559, VSP_035560;
CC -!- SIMILARITY: Belongs to the SOLO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD58743.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB096104; BAC78395.1; -; mRNA.
DR EMBL; AL732415; CAD58743.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL732458; CAD61241.1; -; Genomic_DNA.
DR EMBL; CR848760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC134893; AAI34894.1; -; mRNA.
DR RefSeq; NP_878301.2; NM_182881.2. [Q7SX85-1]
DR RefSeq; XP_005167932.1; XM_005167875.3. [Q7SX85-1]
DR AlphaFoldDB; Q7SX85; -.
DR SMR; Q7SX85; -.
DR STRING; 7955.ENSDARP00000116017; -.
DR PaxDb; Q7SX85; -.
DR Ensembl; ENSDART00000059448; ENSDARP00000059447; ENSDARG00000040614. [Q7SX85-1]
DR Ensembl; ENSDART00000139775; ENSDARP00000116017; ENSDARG00000040614. [Q7SX85-1]
DR Ensembl; ENSDART00000192523; ENSDARP00000152076; ENSDARG00000040614. [Q7SX85-1]
DR GeneID; 360133; -.
DR KEGG; dre:360133; -.
DR CTD; 91404; -.
DR ZFIN; ZDB-GENE-030801-1; sestd1.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00730000111148; -.
DR HOGENOM; CLU_010440_1_0_1; -.
DR InParanoid; Q7SX85; -.
DR OMA; SMDLNFL; -.
DR OrthoDB; 230255at2759; -.
DR PhylomeDB; Q7SX85; -.
DR TreeFam; TF332003; -.
DR PRO; PR:Q7SX85; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000040614; Expressed in blastula and 34 other tissues.
DR ExpressionAtlas; Q7SX85; baseline.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; IBA:GO_Central.
DR GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IBA:GO_Central.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:ZFIN.
DR CDD; cd00170; SEC14; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR SMART; SM00150; SPEC; 2.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..714
FT /note="SEC14 domain and spectrin repeat-containing protein
FT 1"
FT /id="PRO_0000309497"
FT DOMAIN 1..153
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REPEAT 275..381
FT /note="Spectrin 1"
FT REPEAT 384..497
FT /note="Spectrin 2"
FT REPEAT 503..605
FT /note="Spectrin 3"
FT REGION 691..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_035559"
FT VAR_SEQ 211..234
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_035560"
FT CONFLICT 230
FT /note="G -> K (in Ref. 1; BAC78395)"
FT /evidence="ECO:0000305"
FT CONFLICT 627
FT /note="L -> V (in Ref. 1; BAC78395)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 714 AA; 81274 MW; 5008FFC9832405B5 CRC64;
MEASCILPVL KKKLAFLSGG KDRRSGLILT IPLCTEQTSM EELSTTLDYL LGIPSEKCKA
RGFTVIVDGR KSQWNIVKTV VLMLQNVIPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL
GFEVILVSAN KLTRYIEPCQ LTDEFGGSLL YDHLDWVNKR LVFEKFTKES TSLLDELIVI
NENEKGSQAE KDRSSESNIL PSFDPETVLQ TGHELLSELQ QRRFNGSEGG GGGGTAWSPM
DDELLAQPQV MKLLDSLREQ YTKYQEVCRQ RSKRSQLEEI QTKVMQVVNW LEGPGTDQLR
TQWGIGDSIR ASQALQQKHE EIESQHSEWF AVYVELNQQI AALLSAGDEE DLMELKGLQQ
QLSDVCYRQA SQLEFRQNVL QSAYEFHMTA QDLSQQLDGL LGMLCADVAP ADGAAIQQTL
KHLEEKLKSV ESALQTLREK GQALLDQMSN QTSFSYGKEV GVENKENIDH IHSVMEDMQL
RKQRCEDMVD VRRLKMLQMV QLFKCEEDAS QAVEWLGELL DALLKTHIRL GDDSQETKVL
LEKHKKFVDV AQSTYDYGRQ LLQATVVLCQ SLRCTTRSSG DTLPRLNRVW KQFTVTSDER
QHRLEMASAF HTAAEKIVRE SPELAELLVD VEAYEEVETL GKGLLDRLTV PVIFPDGSEQ
FFGSPGDMAS SAESIRERMK LVEEKRFLQE EAEQRLEEEE EEEEAALEVE PRES
