ID   SESD1_XENTR             Reviewed;         696 AA.
AC   Q5M7P4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=SEC14 domain and spectrin repeat-containing protein 1;
GN   Name=sestd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as the primary docking protein directing membrane
CC       turnover and assembly of the transient receptor potential channels
CC       trpc4 and trpc5. Binds phospholipids (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOLO family. {ECO:0000305}.
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DR   EMBL; BC088523; AAH88523.1; -; mRNA.
DR   RefSeq; NP_001011359.1; NM_001011359.1.
DR   AlphaFoldDB; Q5M7P4; -.
DR   SMR; Q5M7P4; -.
DR   STRING; 8364.ENSXETP00000032937; -.
DR   PaxDb; Q5M7P4; -.
DR   PRIDE; Q5M7P4; -.
DR   Ensembl; ENSXETT00000062079; ENSXETP00000058869; ENSXETG00000015051.
DR   GeneID; 496826; -.
DR   KEGG; xtr:496826; -.
DR   CTD; 91404; -.
DR   Xenbase; XB-GENE-977656; sestd1.
DR   eggNOG; KOG4240; Eukaryota.
DR   HOGENOM; CLU_010440_1_0_1; -.
DR   InParanoid; Q5M7P4; -.
DR   OrthoDB; 230255at2759; -.
DR   PhylomeDB; Q5M7P4; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015051; Expressed in heart and 13 other tissues.
DR   GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; IBA:GO_Central.
DR   GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IBA:GO_Central.
DR   GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR   CDD; cd00170; SEC14; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..696
FT                   /note="SEC14 domain and spectrin repeat-containing protein
FT                   1"
FT                   /id="PRO_0000309481"
FT   DOMAIN          1..153
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REPEAT          272..378
FT                   /note="Spectrin 1"
FT   REPEAT          381..494
FT                   /note="Spectrin 2"
FT   REPEAT          500..602
FT                   /note="Spectrin 3"
SQ   SEQUENCE   696 AA;  79421 MW;  C0F8FACA605DE73A CRC64;
     MDATVILPIL KKKLAFLSGG KDRRSGLILT IPLCSDQTSM DELSVTLDYL LSIPSDKCKA
     RGFTVIVDGR KSQWNVVKTV VLMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL
     GFEVILVSGN KLTRYIEPNQ LTEEFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELAVI
     NNGSDKGSQN EKERSVDFNY LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE
     LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLDEIQQK VMQVVNWLEG PGSEQLRTQW
     GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKTLQQRLS
     DVCYRQASQL EFRQNLLQTA LDFHSVAQDL SQQLDGLLGM LCVDVAPTDG AAIQQTLKLL
     EEKLKSVDTG LQGLREKGQG LLDQITNQAS WAYGKDVSTE NKDNVDHIQG IMEDMQLRKQ
     RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV DWLNELLDAL LKTHIRLGDD SQETKILLEK
     HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PKLNRVWKQF TITSEERVHR
     LEMALAFHSN AEKILQECPD LGETVMDFEQ FDEVEAVGKS VLDRLTVPVI YPDGTEQYFG
     TPSDMASTAE HIRERIKMVC LKKQQLLEPD ESIRES