ID   SESN1_CAEEL             Reviewed;         474 AA.
AC   Q9N4D6;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 3.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Sestrin homolog {ECO:0000305};
GN   Name=sesn-1 {ECO:0000312|WormBase:Y74C9A.5};
GN   ORFNames=Y74C9A.5 {ECO:0000312|WormBase:Y74C9A.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=23318476; DOI=10.1016/j.exger.2012.12.011;
RA   Yang Y.L., Loh K.S., Liou B.Y., Chu I.H., Kuo C.J., Chen H.D., Chen C.S.;
RT   "SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.";
RL   Exp. Gerontol. 48:371-379(2013).
CC   -!- FUNCTION: May function as a negative feedback regulator of TOR
CC       function. {ECO:0000250|UniProtKB:Q9W1K5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6P5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9Y6P5}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in decreased
CC       lifespan. {ECO:0000269|PubMed:23318476}.
CC   -!- SIMILARITY: Belongs to the sestrin family. {ECO:0000305}.
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DR   EMBL; FO080986; CCD68266.1; -; Genomic_DNA.
DR   RefSeq; NP_490664.2; NM_058263.4.
DR   AlphaFoldDB; Q9N4D6; -.
DR   SMR; Q9N4D6; -.
DR   BioGRID; 37099; 2.
DR   STRING; 6239.Y74C9A.5.2; -.
DR   PaxDb; Q9N4D6; -.
DR   EnsemblMetazoa; Y74C9A.5.1; Y74C9A.5.1; WBGene00022279.
DR   EnsemblMetazoa; Y74C9A.5.2; Y74C9A.5.2; WBGene00022279.
DR   GeneID; 171593; -.
DR   KEGG; cel:CELE_Y74C9A.5; -.
DR   UCSC; Y74C9A.5; c. elegans.
DR   CTD; 171593; -.
DR   WormBase; Y74C9A.5; CE40291; WBGene00022279; sesn-1.
DR   eggNOG; KOG3746; Eukaryota.
DR   GeneTree; ENSGT00950000183168; -.
DR   HOGENOM; CLU_489386_0_0_1; -.
DR   InParanoid; Q9N4D6; -.
DR   OMA; GSHMTEF; -.
DR   OrthoDB; 588598at2759; -.
DR   PhylomeDB; Q9N4D6; -.
DR   Reactome; R-CEL-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-CEL-9755511; KEAP1-NFE2L2 pathway.
DR   PRO; PR:Q9N4D6; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00022279; Expressed in larva and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070728; F:leucine binding; IBA:GO_Central.
DR   GO; GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IBA:GO_Central.
DR   GO; GO:0071233; P:cellular response to leucine; IBA:GO_Central.
DR   GO; GO:1990253; P:cellular response to leucine starvation; IBA:GO_Central.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IBA:GO_Central.
DR   GO; GO:1901031; P:regulation of response to reactive oxygen species; IEA:InterPro.
DR   InterPro; IPR029032; AhpD-like.
DR   InterPro; IPR006730; Sestrin.
DR   PANTHER; PTHR12474; PTHR12474; 1.
DR   Pfam; PF04636; PA26; 1.
DR   SUPFAM; SSF69118; SSF69118; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..474
FT                   /note="Sestrin homolog"
FT                   /id="PRO_0000221185"
SQ   SEQUENCE   474 AA;  55108 MW;  56ED7FF49BE9C0C1 CRC64;
     MHTTTKRRKA MDWLNFDPIP EVDRLFRFTC KHPTLHVHMT GSYGHMFVDI SDLPASARHY
     LALMAASRHR CLSLMDHHRR KFLEKGGQQM WLLGIDWSYM KFRKLDYLNR MLCHRPWMIH
     WKNLAVLFAR RTPDGGPAFF SVCSLHHAVG IMSMTHAMCT VICCIGLERR VDLTQDEIDF
     LNIDDLDYWE ARMSAYFRKV PDRRPTEVEY LISELKKTEK GQTRPPAKMC AMTTETIESL
     ISAPAATYSS NRKNYSPVLL LANIDENGED IMEKEPPCNY PIYSHHRTFG YIDFRKRPEK
     DIPPFRVEEF GWDHVYNTMN EYTDTLTSRL DRMFDHIRTL TGNMPSGSSH ASGDGEPPAA
     VNQNEIDTAA FREAIWNYTQ GLYGVRVDDY DYSKINRVLD KGTKTFIKLA ACYPHKLTTE
     FTRALPGFKD SEKIHVVMMV AMARFQASMF HYTRAVCNYN AMCLSKKGWR KPLD