SESN_DICDI
ID SESN_DICDI Reviewed; 601 AA.
AC Q54WU6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Sestrin homolog {ECO:0000305};
GN ORFNames=DDB_G0279427 {ECO:0000312|dictyBase:DDB_G0279427};
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May function as a negative feedback regulator of TOR
CC function. {ECO:0000250|UniProtKB:Q9W1K5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6P5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9Y6P5}.
CC -!- SIMILARITY: Belongs to the sestrin family. {ECO:0000305}.
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DR EMBL; AAFI02000031; EAL67652.1; -; Genomic_DNA.
DR RefSeq; XP_641621.1; XM_636529.1.
DR AlphaFoldDB; Q54WU6; -.
DR SMR; Q54WU6; -.
DR STRING; 44689.DDB0232929; -.
DR PaxDb; Q54WU6; -.
DR EnsemblProtists; EAL67652; EAL67652; DDB_G0279427.
DR GeneID; 8622027; -.
DR KEGG; ddi:DDB_G0279427; -.
DR dictyBase; DDB_G0279427; sesn.
DR eggNOG; KOG3746; Eukaryota.
DR HOGENOM; CLU_020429_2_1_1; -.
DR InParanoid; Q54WU6; -.
DR OMA; CIFGIRH; -.
DR PhylomeDB; Q54WU6; -.
DR Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR PRO; PR:Q54WU6; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0070728; F:leucine binding; IBA:GO_Central.
DR GO; GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IBA:GO_Central.
DR GO; GO:0071233; P:cellular response to leucine; IBA:GO_Central.
DR GO; GO:1990253; P:cellular response to leucine starvation; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:dictyBase.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IMP:dictyBase.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IMP:dictyBase.
DR GO; GO:1901031; P:regulation of response to reactive oxygen species; IMP:dictyBase.
DR Gene3D; 1.20.1290.10; -; 1.
DR InterPro; IPR029032; AhpD-like.
DR InterPro; IPR006730; Sestrin.
DR PANTHER; PTHR12474; PTHR12474; 1.
DR Pfam; PF04636; PA26; 1.
DR SUPFAM; SSF69118; SSF69118; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Glycoprotein; Nucleus; Reference proteome.
FT CHAIN 1..601
FT /note="Sestrin homolog"
FT /id="PRO_0000356842"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 330
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 388
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 406
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 438
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 499
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 601 AA; 68407 MW; 73E899E964819AF9 CRC64;
MISMGMTSKG QNVDGAPAGN SSSEWIISSS SSPFQANKRY SLDPPFGSDY SPPASPQNEL
DPLSSYFLNL QSEDNDVRKT AIEYIINTLS NPDNEKLIKN HLPMIVVLST ESPFDDISEA
FTNFLKPIQE KYHIPKQRTT VFTSESQLPP LNTDDELTRK LFQDVFLQHG RVNHLTRILG
WHPQYLEKFL LAYNTIMRDP GPLPLHWRNY IGILAAARYK CSYIIALQEH EFLMNNGDAR
WLQGIDHIPA KLKNLLKVIE LLAHQPWLLP KLDIEYLVKG TDAWSIAELV HAMVLICTFL
SLSGFVFCCG ISPECGLSES NNLSSSFSLN DSDCEIEDTA ATENTAKVME LLKNRRSQQQ
DDDDDDQLHD RQQDFHNAGD DSQSSNNNTT TTTTTTTTTT TTTNTNTTSN SAGGGDSSSS
TLSQSSDRMS DFSRYIGNNT MTHTDFDVSS KLYNIFSAQE YSWREHGYEL VSRYFPDAAP
LLDEEFSFVY TMTYYKFNNN TDIDTLPFRR AVWYYVQRVK GMLHDDYNYQ EVNMFLSRSL
KNFVKKAVCF PETIKRDDYS KLGYSLKPDE KCHLSLLAVC SHKQASLLYG LYSVMNYQNR
R
