SESQ1_RAT
ID SESQ1_RAT Reviewed; 234 AA.
AC D3ZL52;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Sesquipedalian-1;
DE Short=Ses1;
DE AltName: Full=27 kDa inositol polyphosphate phosphatase interacting protein A;
DE Short=IPIP27A;
DE AltName: Full=PH domain-containing endocytic trafficking adaptor 1 {ECO:0000250|UniProtKB:Q8N4B1};
GN Name=Pheta1 {ECO:0000312|RGD:1310656};
GN Synonyms=Fam109a {ECO:0000312|RGD:1310656};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH OCRL.
RX PubMed=20133602; DOI=10.1073/pnas.0914658107;
RA Swan L.E., Tomasini L., Pirruccello M., Lunardi J., De Camilli P.;
RT "Two closely related endocytic proteins that share a common OCRL-binding
RT motif with APPL1.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:3511-3516(2010).
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000250|UniProtKB:Q8N4B1}.
CC -!- SUBUNIT: Forms homodimers and heterodimers with PHETA2 (By similarity).
CC Interacts with INPP5B (By similarity) (PubMed:20133602). Interacts with
CC OCRL. Interaction with OCRL may be important for endosomal morphology
CC and function (By similarity) (PubMed:20133602). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q8N4B1, ECO:0000269|PubMed:20133602}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q8N4B1}.
CC Recycling endosome {ECO:0000250|UniProtKB:Q8N4B1}. Golgi apparatus,
CC trans-Golgi network {ECO:0000250|UniProtKB:Q8N4B1}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q8N4B1}.
CC Note=Interaction with OCRL may be crucial for targeting to endosome and
CC to the trans-Golgi network. Also found on macropinosomes. Not detected
CC in late endosomes, nor in lysosomes. {ECO:0000250|UniProtKB:Q8N4B1}.
CC -!- DOMAIN: The F&H motif, an approximately 12-13 amino-acid sequence
CC centered around Phe and His residues, is essential for binding to OCRL
CC and INPP5B. {ECO:0000250|UniProtKB:Q8N4B1}.
CC -!- MISCELLANEOUS: Was named after 'sesquipedalian', an unnecessarily long
CC description of a simple thing. {ECO:0000250|UniProtKB:Q8N4B1}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family. {ECO:0000305}.
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DR EMBL; CH473973; EDM13713.1; -; Genomic_DNA.
DR RefSeq; XP_002724867.1; XM_002724821.4.
DR RefSeq; XP_002728013.1; XM_002727967.4.
DR RefSeq; XP_006221417.1; XM_006221355.3.
DR RefSeq; XP_006249472.1; XM_006249410.3.
DR RefSeq; XP_017454009.1; XM_017598520.1.
DR RefSeq; XP_017459974.1; XM_017604485.1.
DR AlphaFoldDB; D3ZL52; -.
DR SMR; D3ZL52; -.
DR BioGRID; 252645; 1.
DR STRING; 10116.ENSRNOP00000034778; -.
DR PaxDb; D3ZL52; -.
DR Ensembl; ENSRNOT00000030600; ENSRNOP00000034778; ENSRNOG00000028206.
DR Ensembl; ENSRNOT00000098471; ENSRNOP00000086694; ENSRNOG00000028206.
DR Ensembl; ENSRNOT00000102813; ENSRNOP00000094037; ENSRNOG00000028206.
DR Ensembl; ENSRNOT00000108435; ENSRNOP00000085047; ENSRNOG00000028206.
DR Ensembl; ENSRNOT00000110926; ENSRNOP00000076442; ENSRNOG00000028206.
DR GeneID; 288664; -.
DR UCSC; RGD:1310656; rat.
DR CTD; 144717; -.
DR RGD; 1310656; Pheta1.
DR eggNOG; ENOG502QQ94; Eukaryota.
DR GeneTree; ENSGT00940000162791; -.
DR HOGENOM; CLU_060423_0_1_1; -.
DR InParanoid; D3ZL52; -.
DR OMA; NGCAVWN; -.
DR OrthoDB; 1329965at2759; -.
DR PhylomeDB; D3ZL52; -.
DR TreeFam; TF326731; -.
DR PRO; PR:D3ZL52; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Proteomes; UP000234681; Chromosome 12.
DR Bgee; ENSRNOG00000028206; Expressed in jejunum and 19 other tissues.
DR Genevisible; D3ZL52; RN.
DR GO; GO:0030136; C:clathrin-coated vesicle; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; ISO:RGD.
DR GO; GO:0055037; C:recycling endosome; ISO:RGD.
DR GO; GO:0005802; C:trans-Golgi network; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0007032; P:endosome organization; ISO:RGD.
DR GO; GO:0001881; P:receptor recycling; ISO:RGD.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:RGD.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; PTHR22902; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Endosome; Golgi apparatus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..234
FT /note="Sesquipedalian-1"
FT /id="PRO_0000406047"
FT DOMAIN 17..113
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 134..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 191..203
FT /note="F&H"
FT MOD_RES 183
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N4B1"
SQ SEQUENCE 234 AA; 25793 MW; 686F1B4DDEA6D29A CRC64;
MKLNERSLAF YATCDAPVDN AGFLYKRGGR GAGSHRRWFV LRGNILFYFE SESSREPLGV
ILLEGCTVEL VDAREEFAFA VRFAGGRSRP YVLAADSQAA LEGWVKALSR ASFHYLRLVV
RELEQQLAAM REGSPANALP DANPSTVLNP KPKENGRAVW SALPEQPAVA PRRPPLPPRR
RASAANGPSV SFAQLHERYG LEVRALRNQW RGGLTSLEVP CHPGSGETQT QDQP
