ID   SESQ2_BOVIN             Reviewed;         259 AA.
AC   Q1RMU7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Sesquipedalian-2;
DE            Short=Ses2;
DE   AltName: Full=27 kDa inositol polyphosphate phosphatase interacting protein B;
DE            Short=IPIP27B;
DE   AltName: Full=PH domain-containing endocytic trafficking adaptor 2 {ECO:0000250|UniProtKB:Q6ICB4};
GN   Name=PHETA2 {ECO:0000250|UniProtKB:Q6ICB4}; Synonyms=FAM109B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC       recycling from endosomes, both to the trans-Golgi network and the
CC       plasma membrane. {ECO:0000250|UniProtKB:Q6ICB4}.
CC   -!- SUBUNIT: Forms homodimers and heterodimers with PHETA1. Interacts with
CC       OCRL and INPP5B. {ECO:0000250|UniProtKB:Q6ICB4}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q6ICB4}.
CC       Recycling endosome {ECO:0000250|UniProtKB:Q6ICB4}. Golgi apparatus,
CC       trans-Golgi network {ECO:0000250|UniProtKB:Q6ICB4}. Cytoplasmic
CC       vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q6ICB4}.
CC       Note=Also found on macropinosomes. Not detected in late endosomes, nor
CC       in lysosomes. {ECO:0000250|UniProtKB:Q6ICB4}.
CC   -!- DOMAIN: The F&H motif, an approximately 12-13 amino-acid sequence
CC       centered around Phe and His residues, is essential for binding to OCRL
CC       and INPP5B. {ECO:0000250|UniProtKB:Q8N4B1}.
CC   -!- MISCELLANEOUS: Was named after 'sesquipedalian', an unnecessarily long
CC       description of a simple thing. {ECO:0000250|UniProtKB:Q6ICB4}.
CC   -!- SIMILARITY: Belongs to the sesquipedalian family. {ECO:0000305}.
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DR   EMBL; BC114700; AAI14701.1; -; mRNA.
DR   RefSeq; NP_001039401.2; NM_001045936.2.
DR   AlphaFoldDB; Q1RMU7; -.
DR   SMR; Q1RMU7; -.
DR   STRING; 9913.ENSBTAP00000012510; -.
DR   PaxDb; Q1RMU7; -.
DR   PRIDE; Q1RMU7; -.
DR   GeneID; 506148; -.
DR   KEGG; bta:506148; -.
DR   CTD; 150368; -.
DR   eggNOG; ENOG502QQ94; Eukaryota.
DR   HOGENOM; CLU_060423_0_1_1; -.
DR   InParanoid; Q1RMU7; -.
DR   OrthoDB; 1329965at2759; -.
DR   TreeFam; TF326731; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR045188; Boi1/Boi2-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22902; PTHR22902; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasmic vesicle; Endosome; Golgi apparatus;
KW   Reference proteome.
FT   CHAIN           1..259
FT                   /note="Sesquipedalian-2"
FT                   /id="PRO_0000254132"
FT   DOMAIN          17..121
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   COILED          124..149
FT                   /evidence="ECO:0000255"
FT   MOTIF           223..235
FT                   /note="F&H"
SQ   SEQUENCE   259 AA;  28626 MW;  8936E7AB4C01C930 CRC64;
     MKLNERSVAH YALSDSPADH TGFLRTWGGA GTPPTPSGAG RKCWFVLKGN LLFSFESREG
     RAPLSLVVLE GCTVELAEAP VPEEFAFAIR FDAPGVRPHL LAADGPAAQE AWVKALSRAS
     FGYMRLVVRE LESQLREARH SLDLHRRSSW KAVSSRCKPQ APDRWSPGLE NGHSLSRDCS
     PMGLVEEGGS RPAGRGLAEW ELQGPASLLL GRGQSPVSPE TSCFSTLHEW YGREIMELRR
     AWLQRAQENQ PECKDQDRP