ID   SET14_CAEEL             Reviewed;         429 AA.
AC   Q09415; Q09414;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=SET domain-containing protein 14;
GN   Name=set-14; ORFNames=R06F6.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; Z46794; CAA86783.1; -; Genomic_DNA.
DR   PIR; T23984; T23984.
DR   RefSeq; NP_496323.1; NM_063922.4.
DR   AlphaFoldDB; Q09415; -.
DR   SMR; Q09415; -.
DR   BioGRID; 39975; 6.
DR   DIP; DIP-24607N; -.
DR   IntAct; Q09415; 1.
DR   STRING; 6239.R06F6.4; -.
DR   EPD; Q09415; -.
DR   PaxDb; Q09415; -.
DR   PeptideAtlas; Q09415; -.
DR   EnsemblMetazoa; R06F6.4.1; R06F6.4.1; WBGene00011068.
DR   GeneID; 174662; -.
DR   KEGG; cel:CELE_R06F6.4; -.
DR   CTD; 174662; -.
DR   WormBase; R06F6.4; CE16303; WBGene00011068; set-14.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_631973_0_0_1; -.
DR   InParanoid; Q09415; -.
DR   OMA; CHSYIDE; -.
DR   OrthoDB; 981799at2759; -.
DR   PhylomeDB; Q09415; -.
DR   Reactome; R-CEL-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q09415; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00011068; Expressed in germ line (C elegans) and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF01753; zf-MYND; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..429
FT                   /note="SET domain-containing protein 14"
FT                   /id="PRO_0000218322"
FT   ZN_FING         26..64
FT                   /note="MYND-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         39
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         42
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         48
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         52
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         60
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
SQ   SEQUENCE   429 AA;  48546 MW;  51F223A6D0B56BA9 CRC64;
     MNLPPDALHE NVYAFALARD QVESYCNQCL TSMAELKKCS ACRRLAYCSQ ECQRADWKLH
     KVECKAIKTH NEVANDSIRL VMRIAGKLSR NEDGEIEAYY IPGVARNFQN LEHHPSSYDA
     DEESFVKEYF QFAIAPHPDR DLIKLIFQKV SINSFVVGNS TGNPIGVGLC IKLSAANHSC
     KPLTRVCYRN RTAMLVPVSS ELPSTLEGAC HSYIDELMPR DMRRDTLKKK YKFLCQCDGC
     LDEDRNARME AWTCGICVKG WMRNKENGQC ELCGWTMSKD HFELCRTAEE AGIAARSRLA
     NDAIPLETKR NLCEKLLDLF QDTLHDHNVH RIPVLRCLYI CSLAAQNITA AAKTGGTLLS
     IMLVYQNTTD PAILFQKYQL AQLFCAAGAK TQATKLLQEI EEPLEKIYTP DSMICRNVYC
     MILKARNLS