SET3_CAEEL
ID SET3_CAEEL Reviewed; 465 AA.
AC P34318; Q8I4M9;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=SET domain-containing protein 3;
DE EC=2.1.1.-;
GN Name=set-3; ORFNames=C07A9.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34318-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34318-2; Sequence=VSP_015956;
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; Z29094; CAA82336.1; -; Genomic_DNA.
DR EMBL; Z29094; CAD45581.1; -; Genomic_DNA.
DR PIR; S40701; S40701.
DR RefSeq; NP_499143.1; NM_066742.3. [P34318-1]
DR RefSeq; NP_871669.1; NM_181940.3. [P34318-2]
DR AlphaFoldDB; P34318; -.
DR BioGRID; 47209; 2.
DR IntAct; P34318; 1.
DR STRING; 6239.C07A9.7a; -.
DR EPD; P34318; -.
DR PaxDb; P34318; -.
DR PeptideAtlas; P34318; -.
DR EnsemblMetazoa; C07A9.7a.1; C07A9.7a.1; WBGene00007403. [P34318-1]
DR EnsemblMetazoa; C07A9.7b.1; C07A9.7b.1; WBGene00007403. [P34318-2]
DR GeneID; 182356; -.
DR KEGG; cel:CELE_C07A9.7; -.
DR CTD; 182356; -.
DR WormBase; C07A9.7a; CE00498; WBGene00007403; set-3. [P34318-1]
DR WormBase; C07A9.7b; CE31769; WBGene00007403; set-3. [P34318-2]
DR eggNOG; KOG2084; Eukaryota.
DR HOGENOM; CLU_619999_0_0_1; -.
DR InParanoid; P34318; -.
DR OMA; KNAHTIY; -.
DR OrthoDB; 904757at2759; -.
DR PhylomeDB; P34318; -.
DR PRO; PR:P34318; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007403; Expressed in germ line (C elegans) and 11 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10536; SET_SMYD4; 1.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044421; SMYD4_SET.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..465
FT /note="SET domain-containing protein 3"
FT /id="PRO_0000065163"
FT DOMAIN 18..265
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT VAR_SEQ 425..465
FT /note="LVVKLVNVVANQNADEINRTLEKLKLRARMLWKYSEQSEDL -> YVRYYGD
FT AEKNFGSSSNSSMSLPIRMLTKLTER (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015956"
SQ SEQUENCE 465 AA; 53241 MW; 9ACEE58CF508DE82 CRC64;
MVEVPSFRSN EHFPQLCDKV TVKWDKKRGR FVEAIEDIPI GTVVCVETGI TVNVDPQNCY
RCLKITENAS FAYCKNCEEF YEPDEIACGE FDELGIFKLA AHLVFSYPFA DIASLVQSSD
PEPPSCAPKA LSTQDIEAIF QLTPFPEIGE AFKAPAIQNA IKRIVESLET DENWGRLDQI
SRTMTFTKAL RIMAERSAKN AHTIYSIEQI ESQEDNLPMA TGLFPISSIF NHSCTPNISG
FFVRNTFIFV SQGVRAREEL LDSYGVTYHQ HTFEQRTNFL ASVSGFICHC ESCFKMKSLK
VLEKPKKYPE TIATNASCFT DITSYTENIP RGSKELENLI IAFARRPDSE TYTELIFQFW
KKFVENAKFR GITYDPYLVR PYVEMTILAW NKEVGCENEE KMSLLIVTHR LLRNCYVDLH
PLSELVVKLV NVVANQNADE INRTLEKLKL RARMLWKYSE QSEDL
