ID   SET5_ASHGO              Reviewed;         488 AA.
AC   Q75BF1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=ADL387C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 69-76.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AE016817; AAS51533.2; -; Genomic_DNA.
DR   RefSeq; NP_983709.2; NM_209062.2.
DR   AlphaFoldDB; Q75BF1; -.
DR   STRING; 33169.AAS51533; -.
DR   PRIDE; Q75BF1; -.
DR   EnsemblFungi; AAS51533; AAS51533; AGOS_ADL387C.
DR   GeneID; 4619844; -.
DR   KEGG; ago:AGOS_ADL387C; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q75BF1; -.
DR   OMA; TYVNPLH; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   GO; GO:0000723; P:telomere maintenance; IEA:EnsemblFungi.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..488
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324464"
FT   DOMAIN          111..379
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          415..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55715 MW;  056E0F99090E2DF7 CRC64;
     MGQSSLKLET IPLNDCHFSD AAPVGSVIPT ESEVYDAVAQ LWRQEPELER AGWEEWRARL
     KAIHPGWSLS VAHICRTLEK HCMSITGITQ FTYHELVTSK ESPALREPHL AKVQVTWSEK
     GKGLVARRPL AKGELVFAED ALSFIPPLEK STLVHLSKAC GSCGTSLSQN RYYYVMNNLD
     CDNCTTIWCT KGCRNLDTTH DFLKHPMSRN KRCSAQKWLK FEQFCKENTW HSAYSVGVMF
     ARYYLHSDRR LQGNFESLAE VSQRVRLHAA DTMNSGAAFD LGVDLTANAQ SVCMWEEGYG
     LFCDAFPLAK DEYDLDFEKF LRYVGKFNLN QVNGQIYMLL SHLNHSCEPN IYYELEGHHI
     NVYARKEIKS DEELTVSYVN PLHDVDLRRR ELRVNWGFLC LCDRCKREIS KKNIDKAGHS
     STTAGPEPQS YRGHRRKSSL RASKPTLQDL LENGKEFDIE IPSQPGFAAR RASVRFDSKV
     VTAVEERQ