ID   SET5_CANAL              Reviewed;         473 AA.
AC   Q5A1M3; A0A1D8PN29;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=CAALFM_C500950CA;
GN   ORFNames=CaO19.1972, CaO19.9528;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CP017627; AOW29537.1; -; Genomic_DNA.
DR   RefSeq; XP_715734.2; XM_710641.2.
DR   AlphaFoldDB; Q5A1M3; -.
DR   STRING; 237561.Q5A1M3; -.
DR   PRIDE; Q5A1M3; -.
DR   GeneID; 3642653; -.
DR   KEGG; cal:CAALFM_C500950CA; -.
DR   CGD; CAL0000174761; orf19.9528.
DR   VEuPathDB; FungiDB:C5_00950C_A; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q5A1M3; -.
DR   OrthoDB; 1001347at2759; -.
DR   PRO; PR:Q5A1M3; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IBA:GO_Central.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..473
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324465"
FT   DOMAIN          107..381
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   473 AA;  53880 MW;  0169C0B1F3361452 CRC64;
     MTQDISEKIE VISINDSQPE DSSPVVPHER QVVDCVIEIW KEDPSTESLG MSKLHALVKQ
     KHPNWSISEK RVRSLLKQFG LAFNNQEQFT YAKEITSVMT PDIELPANVH IIMTSKRGKG
     LYAKRDIAKG DLIWSEEPLF FIPPLANVNL MKTASACTYC GKLLQRTESA TVLKGLDCNV
     CSEVWCSIKC KHLDGNLHSL LKHNLYNPGS KKHKLIDAEA FLELQDYCLE EQWNALYAIT
     LIYANCITDK SGVKQKQFDA MARVSQDVRY KALNSSAGTF DSLNGGALFV QEQQEHLWKI
     GYEKFLRVFP KKPVEYREFL FMMGTYNINN LDSNVFLTQS HLNHNCASNT SVETELNRTA
     GLKVIAGRDI KSGEELTTTY VNPSHTVHQR QRELRVNWGF ICACAKCKDD LKQNERRKSS
     HNQQQNANNI RDMLKETKDA VGEEGIELEI PTEFNGERRK SVRFDEKVVA VKE