ID   SET5_CANGA              Reviewed;         515 AA.
AC   Q6FTT0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=CAGL0F09119g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CR380952; CAG59288.1; -; Genomic_DNA.
DR   RefSeq; XP_446364.1; XM_446364.1.
DR   AlphaFoldDB; Q6FTT0; -.
DR   STRING; 5478.XP_446364.1; -.
DR   EnsemblFungi; CAG59288; CAG59288; CAGL0F09119g.
DR   GeneID; 2887694; -.
DR   KEGG; cgr:CAGL0F09119g; -.
DR   CGD; CAL0129802; CAGL0F09119g.
DR   VEuPathDB; FungiDB:CAGL0F09119g; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q6FTT0; -.
DR   OMA; TYVNPLH; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0034968; P:histone lysine methylation; IEA:EnsemblFungi.
DR   GO; GO:0000723; P:telomere maintenance; IEA:EnsemblFungi.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..515
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324466"
FT   DOMAIN          114..386
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          452..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  58984 MW;  D7838E98B613ECE8 CRC64;
     MSVSQLKIQT LTLNDSEPSL PGKPITPSKE QIRDDVVLLW KEEPAAEDLD LPHLYDKMKI
     RNTDWQFDIN TLEDVLVSNN LYSVDDSQMD SYNDKIEFPD ISEVMHLVND KLPSKVEIRE
     CEELRKGRGL YATRDIQQGE LLFHEKVPIA MVPPMDKLKL IRSGKSCSMC GVSLSNSSHF
     TMLHGLDCNG CNSIWCSTNC KQKDITHPYL KHFGSKNKNI RPMDWNMFER HCQENIFVAA
     YSIGVIHAAS LIDKAQSDEI NQQFEALAKI SQRVRYESSD SNNIGGTFDA EIGSLKEENP
     EPLWKKAFDL FIRTFPDTAE MGYEVFLEYL GRFHINQLSG QLYFLYSFLN HNCEPNVRYD
     INNKLELKVY ARKFIKKDEE LVTTYVNPLH GVSLRRRELR VNWGFICNCD RCAKEIELRK
     KNAVSIRETV LNSNSSSEVS LRSGLNVTSP IALQRSNGGS SSDLRRKSSI RNRKPDLKEM
     LKNSKEFELE APAALGRNRS TSVRFDDIVS MAVEE