ID   SET5_CRYNJ              Reviewed;         449 AA.
AC   P0CR42; Q55Y21; Q5KLW8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=CNB03780;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AE017342; AAW41903.1; -; Genomic_DNA.
DR   RefSeq; XP_569210.1; XM_569210.1.
DR   AlphaFoldDB; P0CR42; -.
DR   STRING; 5207.AAW41903; -.
DR   PaxDb; P0CR42; -.
DR   EnsemblFungi; AAW41903; AAW41903; CNB03780.
DR   GeneID; 3255780; -.
DR   KEGG; cne:CNB03780; -.
DR   VEuPathDB; FungiDB:CNB03780; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; P0CR42; -.
DR   OMA; HGGLYVL; -.
DR   OrthoDB; 1001347at2759; -.
DR   Proteomes; UP000002149; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IBA:GO_Central.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..449
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324467"
FT   DOMAIN          93..410
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   449 AA;  50784 MW;  A9935238C6D474F0 CRC64;
     MTDLTAEAAI SPSDDILLPA LASLREGHPD KGILKLLAQL KIDHPEWAVS EKRFRKALQL
     APCPGGGEAD PKEKALVADT GLDPSIDVKS IAPKVEVKMF AGGKGKGLVA KEELKQGEML
     WQEEPWIVTS DPGHYSLLTQ SMMCSQCFSL FARPSPPLSV PCPHCTTAHF CNRLCYTKSL
     SSSHPPLLCP GLNPDASSLM NFIRKRGERS VEGVAKILAR WRGEREWDAK GKAEEMEKRI
     WKGMARVSQK RKEMERREWS YISKARMEEW HLIHIMLTNV LNPSPTHENY KPFQRLLISQ
     HPRRSKPVPL TEKEVKRWFS FESFLELLGL VGLNQEDSGG LYALHAHMNH SCEPNIQVRN
     LPKSYTPPTQ DTLPVNLPPP IQAGDRVSNK LTILARHEIQ PGEELTISYV NMKMSRDERR
     QALREGYGFW CACDRCMREK EQPNGEKAE