ID   SET5_DEBHA              Reviewed;         493 AA.
AC   Q6BSV3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=DEHA2D05764g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; CR382136; CAG86859.2; -; Genomic_DNA.
DR   RefSeq; XP_458717.2; XM_458717.2.
DR   AlphaFoldDB; Q6BSV3; -.
DR   STRING; 4959.XP_458717.2; -.
DR   EnsemblFungi; CAG86859; CAG86859; DEHA2D05764g.
DR   GeneID; 2901252; -.
DR   KEGG; dha:DEHA2D05764g; -.
DR   VEuPathDB; FungiDB:DEHA2D05764g; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q6BSV3; -.
DR   OMA; HGGLYVL; -.
DR   OrthoDB; 1001347at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:UniProt.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..493
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324468"
FT   DOMAIN          116..400
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   493 AA;  55485 MW;  43AC2B5CDB24E092 CRC64;
     MMETESKADT ASLANKFEVV DINDYEAESS EPIVPHERQI VDDVIAIWKQ DPSTETLGIG
     KLHAMVKGRH PNWSVSEKRV KTLLKNFGLL TNNANQQFTY ANEIKSLNTP DIDLPEKVHI
     VMTAKRGKGL YAKNKISKGD LIWEESQLFY IAPLANVNLI KGGKACSYCG KLLTQSSSNA
     GISVLKGLDC NVCSEIWCSQ TCKKIDSQLH GMLKHNLYNP NSSGGSKKLI NANAYLELQD
     YCLKEQWNAL YAITIIYANI ITDKSGIKGK QFRAMARVSQ DVRYKALNSS AGAFDNLQGG
     ALFVGEQQEK LWKDGYNRFK NVFPKSVDNG DISYQEFMYM MGTYNINNLD SCIYLTQSHL
     NHNCDPNTNV ETSTTVRTNG LKVFAARDIR AGEELTTTYV NPAYTVQQRQ RELRVNWGFM
     CGCQKCKEDL KCQQRRKSSS APAAKDDKGI REMLMDTKKE IGDQEIELEI PSSYDGERRK
     SVRFDEKVIA VSE