ID   SET5_KLULA              Reviewed;         492 AA.
AC   Q6CX91;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=KLLA0A10241g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CR382121; CAH03036.1; -; Genomic_DNA.
DR   RefSeq; XP_451448.1; XM_451448.1.
DR   AlphaFoldDB; Q6CX91; -.
DR   STRING; 28985.XP_451448.1; -.
DR   PRIDE; Q6CX91; -.
DR   EnsemblFungi; CAH03036; CAH03036; KLLA0_A10241g.
DR   GeneID; 2896390; -.
DR   KEGG; kla:KLLA0_A10241g; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q6CX91; -.
DR   OMA; TYVNPLH; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0034968; P:histone lysine methylation; IEA:EnsemblFungi.
DR   GO; GO:0000723; P:telomere maintenance; IEA:EnsemblFungi.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..492
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324469"
FT   DOMAIN          113..384
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          425..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  56020 MW;  968851A5E63E5520 CRC64;
     MVHLKLETLR LNDEDQSTGS SLITPSRTQL CDEVVRWWKE EPAAEDMLID TLYEHLIRRR
     SNWSVTKDEL YQALKSHKLY TPELNELDSY TGDIRPSTVT DADIAQLNKK LLDKVTIADT
     EFGKGLVATD DIRKGGLVFH EQLPLTVIPQ LDKQPLVSRG KCCGLCSAFT TLSSQLIIKN
     NLDCNMCNTI WCSKQCKKLD TTHSVLKHAT SRNSLCNSSN WIKFENFCLQ ESLVAAYAVG
     VIYARHVMQP TSNLWKLFTS LCSVSQRVRW QASDSINVGG TFDASCNGKL YADVSAPNME
     TQWSDAFEMF AKSFPKCDMD YEDFLNLTGT FNLNQIMGQV YPLVAHINHS CEPNVRYELE
     PKHGIKLYAR KDIKKGEQLR LTYVNPLHGV TLRRRELRVN YGFLCHCPRC CQEWEKRQKI
     VSDPSNHAIS SEAAHSSTTA RRKSSMKSCR PSLKELLENG DEFDLEIPSD VNSKRRMSVR
     FNSHVTLAVE EE