ID   SET5_PICGU              Reviewed;         483 AA.
AC   A5DQN2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; ORFNames=PGUG_05583;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CH408161; EDK41485.2; -; Genomic_DNA.
DR   RefSeq; XP_001482563.1; XM_001482513.1.
DR   AlphaFoldDB; A5DQN2; -.
DR   STRING; 4929.XP_001482563.1; -.
DR   PRIDE; A5DQN2; -.
DR   EnsemblFungi; EDK41485; EDK41485; PGUG_05583.
DR   GeneID; 5124202; -.
DR   KEGG; pgu:PGUG_05583; -.
DR   VEuPathDB; FungiDB:PGUG_05583; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; A5DQN2; -.
DR   OMA; HGGLYVL; -.
DR   OrthoDB; 1001347at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:UniProt.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..483
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324470"
FT   DOMAIN          110..389
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          420..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  54585 MW;  06815ADD03D96758 CRC64;
     MIDKLDGQQE PKVEILDIND HVQESSDPVV PHERQIIDDI IAIWKEDPSS ESLGVPKLHA
     KVKSRHPTWS VSEKRVRTLL KTYGLITTNQ QFTYANEIHS RIVSSIELPP KVKVTMTAKR
     GKGLYAKTQI RKGDLIWEER PLFFVPALAN VKLVRTGRAC AYCAKLLTQR SSTGLSALRG
     LDCNVCPELW CSKDCKTLDT LHAKLKHNMS SHSNGKGSNL IDASGFIALE DYCFQEQWNA
     LYAITLIYAE MQADKTRTKA EYFSSMARVS QKVRYKAINS SAGSFDTMQG GALFVMEQQE
     ALWNEGYQKF LKVFPSAHDQ VPFEEFMMMM GTYNINNLDS CIFLTQSHLN HSCHPNTDVQ
     ASTASRTGPL KVFAARDIKA GEELTTSYVN PSHTLHQRQR ELRVNWGFIC SCQRCKDEAK
     EHHRRKSSNG MGAKEVPSNI REMLKDTKSA IGNSEIELEI PTVQGGERRK SVRFDEHVIS
     VNQ