ID   SET5_PICST              Reviewed;         478 AA.
AC   A3M0J3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; ORFNames=PICST_63965;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CP000502; ABN68716.2; -; Genomic_DNA.
DR   RefSeq; XP_001386745.2; XM_001386708.1.
DR   AlphaFoldDB; A3M0J3; -.
DR   SMR; A3M0J3; -.
DR   STRING; 4924.XP_001386745.2; -.
DR   EnsemblFungi; ABN68716; ABN68716; PICST_63965.
DR   GeneID; 4841014; -.
DR   KEGG; pic:PICST_63965; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; A3M0J3; -.
DR   OMA; HGGLYVL; -.
DR   OrthoDB; 1001347at2759; -.
DR   Proteomes; UP000002258; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:UniProt.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..478
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324471"
FT   DOMAIN          109..387
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   478 AA;  53851 MW;  14BB48DC5B270B58 CRC64;
     MTAEGLEKKI EVISINDSVP QETGPVVPHE RQVVDAIIAI WKEDPTTESL GIPKLHAIVK
     NKYPNWSVSE KRVKTLLKKF GLTPNTNTEQ FTYASDITSE DTPHIQLPAK IQIVMTSKRG
     KGLYAKHKIA KGELIWEETP LFFIPPLANI NLVKTGKACS HCGKLLQTTT GSSMLKGLDC
     NVCPEVWCSQ QCKKLDSAIH GLLKHNVYNP NKRLTSSKII DSESFLELQE YCLKESWNAL
     YAIALIYANI LLDKTGVKEK QFRAMARVSQ DIRYKALNSS AGAFDTLSGG ALFVQEQQET
     LWREGFEKFI RVFPTSTSKL TYKEFLFMMG TYNINNLDSC IFLTQSHLNH NCDPNTNVDT
     SPVRTEGLKV YAARDIRAGE ELTTTYVNPA HTVQQRQREL RVNWGFICGC QKCKEDVKIQ
     HRRKSSTVPA ASKSEIRDML KAAENHVGEE GIELTPPEVS GERRKSVRFD EKVIAVQE