ID   SET5_VANPO              Reviewed;         499 AA.
AC   A7TPV3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; ORFNames=Kpol_1000p13;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; DS480448; EDO15701.1; -; Genomic_DNA.
DR   RefSeq; XP_001643559.1; XM_001643509.1.
DR   AlphaFoldDB; A7TPV3; -.
DR   STRING; 436907.A7TPV3; -.
DR   PRIDE; A7TPV3; -.
DR   EnsemblFungi; EDO15701; EDO15701; Kpol_1000p13.
DR   GeneID; 5543809; -.
DR   KEGG; vpo:Kpol_1000p13; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; A7TPV3; -.
DR   OMA; TYVNPLH; -.
DR   OrthoDB; 1001347at2759; -.
DR   PhylomeDB; A7TPV3; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:UniProt.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..499
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324473"
FT   DOMAIN          112..386
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   499 AA;  56620 MW;  964EB908CCF93862 CRC64;
     MHLKFHTLSL NDSGPLLAES SVKPSQQQIC DDILLLWREE PITDGLSVDL LYDKVMGRHP
     EWILDRTEFK NAVRNQHLDS NDERSLKVYN DFIDIPSFND DYDAIIDKKT SSNVCVKNCK
     DGHKGRGLYA LKDFVKDDLI FKESYPIVVV PSMERLTLMK MGKACSLCGG LLSHLSKHFI
     VVHSLDCDNC GGVWCSNECK NIDIGHNTLK HLHKSKINGI DSVAWGKFEK YCNDNVFVAA
     YSIGVIMALA LIDKKNTDKI RKKFNLLSSV SQGIRINESD STNIGGTFDA SSGAMSNKDP
     EPIWKTSYEL LKNAIPTTDE LDMETYLSYI GRYNINQISD QMFFLPSLIN HNCEPNVRFE
     VVSNKEIRVY ARKNISAGQE LLTNYINPLH GVKLRRRELR VNYGFLCHCD RCIKEIKRNN
     DVENENLSNS INNNGGLSVP NDSLLTRRKS SMRTARPDLS ELLKTGQEFD LDIPENLSGK
     KNRRTSVRFV NQVTLAVEE