ID   SET5_YARLI              Reviewed;         438 AA.
AC   Q6C9E7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; OrderedLocusNames=YALI0D11792g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Putative protein lysine methyltransferase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CR382130; CAG80903.1; -; Genomic_DNA.
DR   RefSeq; XP_502715.1; XM_502715.1.
DR   AlphaFoldDB; Q6C9E7; -.
DR   STRING; 4952.CAG80903; -.
DR   PRIDE; Q6C9E7; -.
DR   EnsemblFungi; CAG80903; CAG80903; YALI0_D11792g.
DR   GeneID; 2910600; -.
DR   KEGG; yli:YALI0D11792g; -.
DR   VEuPathDB; FungiDB:YALI0_D11792g; -.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   InParanoid; Q6C9E7; -.
DR   OMA; HGGLYVL; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IBA:GO_Central.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..438
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324474"
FT   DOMAIN          107..360
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          409..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  50808 MW;  6763C726E583D5AB CRC64;
     MLGLRDVCFD PMLSSYDYHP ISLMSTVPND REIVQAVVDI WRKDKATEKL GAAKLTGLVK
     LTHSDWQLSE KRVKTVMKAA NLGLNQEKFC YAGSIMSHAT PGLDMPEKVT LNIAKNRGKG
     LYAKKDIKKD EELWNEQAFL LVPPLEHVGI MRKGMGCAFC SRPFQSHNGV ECPSCAAKWC
     DNQCKKKDVT HVAMWHESRH GKVTRVEWRA FEDFCVENGW MALYALGLLW LRVIRDPKKD
     EVQKQMMAFA RVGQDERHKA VEQSNSLFAS EQSEVLWKKG YEMLDKLLLD TEFSYEKDFL
     PGLGMFNINN VDGNMYLTQS HLNHSCEPNV DVKNVGRTQG ISVRAKRDIK TGEELFTTYV
     NPEHQLDDRR YNLRVNWGFN CNCTRCKREE REEMEYLDEL VSNWTIEHKR KEMKEEKKER
     TRTRTRSVHF DKEPEVVA