ID   SET5_YEAS7              Reviewed;         526 AA.
AC   A6ZTB4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Potential protein lysine methyltransferase SET5;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 5;
GN   Name=SET5; ORFNames=SCY_2598;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Putative protein lysine methyltransferase that acts as a
CC       virus host factor involved in the replication of positive-strand RNA
CC       viruses like the MBV. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AAFW02000082; EDN62445.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZTB4; -.
DR   EnsemblFungi; EDN62445; EDN62445; SCY_2598.
DR   HOGENOM; CLU_031650_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006479; P:protein methylation; IEA:UniProt.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Phosphoprotein;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..526
FT                   /note="Potential protein lysine methyltransferase SET5"
FT                   /id="PRO_0000324475"
FT   DOMAIN          112..403
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          450..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         517
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P38890"
SQ   SEQUENCE   526 AA;  60574 MW;  11022A6C43C22C7D CRC64;
     MTLTIKIGTL NDSDQSAVHN GTENGSDFRK ITPTEEEICD DVVLLWKEEP GTEDATIQHL
     YDRITERNQS WKLSASRFRK ILNEHHLYDT DLETVSLYKD KIHFPKALDS DAKVEVKFID
     DEHGRGLFAK RDFSKGQIIL KENKPIVYIP PLDKLFLISN GKACARCGKA LYDLTQHKIM
     VHYLDCEVCK AIWCSEKCKK AHASLHELLY HSWRSNRIDI LHAGNWKRFV NYCEKYCFTA
     AFSVGLIYGS MLLDTTGEVK EQWQKLASIS QRERIKLRDA SGIGSTFSLL NGTTVHTEEE
     SDNGTKKGVE KNIDDETVWE KCYELFCGAF PKASEEIDFE KFLTMIGTFN INQYNGQVYH
     WISFINHDCE PNAYIEQVEE HEELRLHARK PIKKGEQIRI TYVNPLHGVR LRRRELRVNW
     GFLCQCDRCQ NELSTFERVP NLEKKNADAN LGVEKIDSND NSEDGSKKST GNRKSSMREA
     QPDLKEILKN GKEFELDIPE TVDTQGNVRK TSVRFDSNVS VAVDER