ID   SET8_SCHPO              Reviewed;         429 AA.
AC   O14135;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=SET domain-containing protein 8;
DE            EC=2.1.1.-;
GN   Name=set8; ORFNames=SPAC3C7.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; CU329670; CAB16739.1; -; Genomic_DNA.
DR   PIR; T38695; T38695.
DR   RefSeq; NP_593610.1; NM_001019041.2.
DR   AlphaFoldDB; O14135; -.
DR   SMR; O14135; -.
DR   BioGRID; 279590; 15.
DR   STRING; 4896.SPAC3C7.09.1; -.
DR   MaxQB; O14135; -.
DR   PaxDb; O14135; -.
DR   EnsemblFungi; SPAC3C7.09.1; SPAC3C7.09.1:pep; SPAC3C7.09.
DR   GeneID; 2543159; -.
DR   KEGG; spo:SPAC3C7.09; -.
DR   PomBase; SPAC3C7.09; set8.
DR   VEuPathDB; FungiDB:SPAC3C7.09; -.
DR   eggNOG; KOG1337; Eukaryota.
DR   HOGENOM; CLU_044629_0_0_1; -.
DR   InParanoid; O14135; -.
DR   OMA; WIHADAL; -.
DR   PhylomeDB; O14135; -.
DR   PRO; PR:O14135; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISM:PomBase.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   InterPro; IPR011219; Rubisco-cyt_methylase_MET.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF026986; MET_SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..429
FT                   /note="SET domain-containing protein 8"
FT                   /id="PRO_0000303896"
FT   DOMAIN          17..232
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   429 AA;  49598 MW;  1C75F9FD5583BE4D CRC64;
     MDIKYNELVN QFAPGAKQIT IKKIRKKGNG IFSLNRYTSG TVLLEVPLEN IICRKTVEQF
     RNSCDKFASI ATLEEWNDMS FRTQAMLFLC YLWLGIQPRT NKWDKFLTVL PLSINTPAQW
     PEKEVYSLQG TSIFNPVCVK RKILQQEWLS LNQRYSDSWP SKITLPKWVH ADALFHSRCL
     ESPFKDPVLA PVIDLCNHSS KSNAKWSFSE DAMQLYLDKD IDENEEVTIN YGSEKGSAEF
     LFSYGFLPEP EGDRITNVMK LLIPEDSNDS LDLAKRRSCK TPPMIEFVSD SSGELWWHAP
     FLFFSVLNVE DFTNFKMVCD ESKAQTVDWE FEGQKCSVED LPKLVQLSPK RDLYILRVFC
     LAEQLADAAL NTNIENMYNP TERRSESVEL LKRESFLLKK VLLYLRDVIS KLLKSKVVVE
     FIHSQTIES