ID   SET9_CHAGB              Reviewed;         734 AA.
AC   Q2H8D5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9;
DE            EC=2.1.1.372 {ECO:0000250|UniProtKB:Q9USK2};
DE   AltName: Full=SET domain protein 9;
GN   Name=SET9; ORFNames=CHGG_03519;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Histone methyltransferase that trimethylates 'Lys-20' of
CC       histone H4 to form H4K20me3. {ECO:0000250|UniProtKB:Q9USK2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, Rhea:RHEA-
CC         COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.372;
CC         Evidence={ECO:0000250|UniProtKB:Q9USK2, ECO:0000255|PROSITE-
CC         ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. Suvar4-20
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00900}.
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DR   EMBL; CH408030; EAQ91584.1; -; Genomic_DNA.
DR   RefSeq; XP_001230035.1; XM_001230034.1.
DR   AlphaFoldDB; Q2H8D5; -.
DR   SMR; Q2H8D5; -.
DR   STRING; 38033.XP_001230035.1; -.
DR   PRIDE; Q2H8D5; -.
DR   EnsemblFungi; EAQ91584; EAQ91584; CHGG_03519.
DR   GeneID; 4388557; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   HOGENOM; CLU_013724_0_0_1; -.
DR   InParanoid; Q2H8D5; -.
DR   OMA; FANHDCG; -.
DR   OrthoDB; 953612at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0034770; P:histone H4-K20 methylation; IEA:InterPro.
DR   Gene3D; 1.10.10.1700; -; 1.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR   InterPro; IPR025783; Set9_fungi.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR039977; Suv4-20/Set9.
DR   PANTHER; PTHR12977; PTHR12977; 2.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..734
FT                   /note="Histone-lysine N-methyltransferase SET9"
FT                   /id="PRO_0000281801"
FT   DOMAIN          116..230
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          343..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  81046 MW;  97B199EF0625EDD9 CRC64;
     MPRAPTSAIK KQPLTFAQLA AYDDILTDAL IDHVYYWTAI PKNRPLYHPS RGIREEEITK
     IIQTHLIVDP DLAIAEEKLL ATDGLRKFHN SLRTDKEKED FKAHLRRYIS IYLPDCPFEV
     NATNRFTIDS YEASITARRP IRRNEAIKYL AGTQVTVTPE EEAQLALRKK DFSLVVSSRS
     KLTSLFMGPA RFANHDCAAN ARLVTRGSAG IEIFACRDIG LGEEITVTYS ESYFGENNCD
     CLCQTCEDNV ANGWKPKDGT VPVHRSIEES VLGDDQGYSL RRRRRERSVS VAGSRTSSVT
     PDIRPRIFKT AKNRAMASDR ASTTDSDGID VVAMAVAAPK RNFDTTALSS PPLTPAKRQK
     PNHYDVVPLP LGLDVSRDSS ASGPVDSLIA TEDEKSTATQ ATTPEFEEPK PPSMREKPLL
     SPEMSPMKEG ATPVGALNGE RDEPTETGAP LSVLPTTETD LPEETLDIAA TTPSLFPSSE
     CSMTANDLPE HITPVSEPPR LTQEGKSVAR QDSQETIIEE SLAVPNSAPS QIQEAENNAQ
     QGAETPVLGA SSLTAEPHNE VAPVISAVST KKKKRRVSEK PAPEPVRKQR VPGDYTLTPL
     LLAQPETAWI HCTNCNTAFV QSDAYYTRAN CSRCERHSKL YGYVWPKTAP AGKNDREERV
     LDHRLINRFL HPDDEAIIRG RKPWRERLGQ SSSSLAPSEE RGRQRESGTP QGTPGDNYRR
     SGRARRASAK AMAQ