SETB_ECOLI
ID SETB_ECOLI Reviewed; 393 AA.
AC P33026;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Sugar efflux transporter B;
GN Name=setB; Synonyms=yeiO; OrderedLocusNames=b2170, JW2157;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RT "Automated multiplex sequencing of the E.coli genome.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP CHARACTERIZATION.
RX PubMed=10209755; DOI=10.1046/j.1365-2958.1999.01321.x;
RA Liu J.Y., Miller P.F., Gosink M., Olson E.R.;
RT "The identification of a new family of sugar efflux pumps in Escherichia
RT coli.";
RL Mol. Microbiol. 31:1845-1851(1999).
RN [6]
RP CHARACTERIZATION.
RX PubMed=10438463; DOI=10.1074/jbc.274.33.22977;
RA Liu J.Y., Miller P.F., Willard J., Olson E.R.;
RT "Functional and biochemical characterization of Escherichia coli sugar
RT efflux transporters.";
RL J. Biol. Chem. 274:22977-22984(1999).
CC -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC be the detoxification of non-metabolizable sugar analogs. Can transport
CC lactose and glucose.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Set
CC transporter family. {ECO:0000305}.
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DR EMBL; U00007; AAA60516.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75231.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15979.1; -; Genomic_DNA.
DR PIR; A64986; A64986.
DR RefSeq; NP_416675.1; NC_000913.3.
DR RefSeq; WP_000551980.1; NZ_LN832404.1.
DR AlphaFoldDB; P33026; -.
DR SMR; P33026; -.
DR BioGRID; 4260465; 101.
DR STRING; 511145.b2170; -.
DR TCDB; 2.A.1.20.2; the major facilitator superfamily (mfs).
DR jPOST; P33026; -.
DR PaxDb; P33026; -.
DR PRIDE; P33026; -.
DR EnsemblBacteria; AAC75231; AAC75231; b2170.
DR EnsemblBacteria; BAA15979; BAA15979; BAA15979.
DR GeneID; 946673; -.
DR KEGG; ecj:JW2157; -.
DR KEGG; eco:b2170; -.
DR PATRIC; fig|1411691.4.peg.68; -.
DR EchoBASE; EB1969; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_055598_3_0_6; -.
DR InParanoid; P33026; -.
DR OMA; FGFTVMY; -.
DR PhylomeDB; P33026; -.
DR BioCyc; EcoCyc:B2170-MON; -.
DR BioCyc; MetaCyc:B2170-MON; -.
DR PRO; PR:P33026; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:EcoliWiki.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IDA:EcoliWiki.
DR GO; GO:0034219; P:carbohydrate transmembrane transport; IMP:EcoCyc.
DR GO; GO:0036448; P:cellular response to glucose-phosphate stress; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IMP:EcoliWiki.
DR GO; GO:1904659; P:glucose transmembrane transport; IDA:EcoliWiki.
DR GO; GO:0015767; P:lactose transport; IDA:EcoliWiki.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004750; Sugar_efflux.
DR PANTHER; PTHR23535:SF2; PTHR23535:SF2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00899; 2A0120; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..393
FT /note="Sugar efflux transporter B"
FT /id="PRO_0000209360"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 393 AA; 42746 MW; 6EC58F00FB632B22 CRC64;
MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP AMVGFFFTGS
AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA WNRNYFVLLF VGVFLSSFGS
TANPQMFALA REHADKTGRE AVMFSSFLRA QVSLAWVIGP PLAYALAMGF SFTVMYLSAA
VAFIVCGVMV WLFLPSMRKE LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP
LFIINELHLP EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML
MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR VGWIIAGSVA
GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV
