ID   SETB_SALTY              Reviewed;         393 AA.
AC   P33027;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Sugar efflux transporter B;
GN   Name=setB; OrderedLocusNames=STM2207;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
RX   PubMed=2546043; DOI=10.1007/bf00334399;
RA   Geerse R.H., Izzo F., Postma P.W.;
RT   "The PEP: fructose phosphotransferase system in Salmonella typhimurium: FPr
RT   combines enzyme IIIFru and pseudo-HPr activities.";
RL   Mol. Gen. Genet. 216:517-525(1989).
CC   -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC       be the detoxification of non-metabolizable sugar analogs. Can transport
CC       lactose and glucose (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Set
CC       transporter family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL21111.1; -; Genomic_DNA.
DR   EMBL; X14243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_461152.1; NC_003197.2.
DR   RefSeq; WP_000551937.1; NC_003197.2.
DR   AlphaFoldDB; P33027; -.
DR   SMR; P33027; -.
DR   STRING; 99287.STM2207; -.
DR   PaxDb; P33027; -.
DR   EnsemblBacteria; AAL21111; AAL21111; STM2207.
DR   GeneID; 1253729; -.
DR   KEGG; stm:STM2207; -.
DR   PATRIC; fig|99287.12.peg.2337; -.
DR   HOGENOM; CLU_055598_3_0_6; -.
DR   OMA; FGFTVMY; -.
DR   PhylomeDB; P33027; -.
DR   BioCyc; SENT99287:STM2207-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0036448; P:cellular response to glucose-phosphate stress; IBA:GO_Central.
DR   GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central.
DR   GO; GO:0015767; P:lactose transport; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004750; Sugar_efflux.
DR   PANTHER; PTHR23535:SF2; PTHR23535:SF2; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00899; 2A0120; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..393
FT                   /note="Sugar efflux transporter B"
FT                   /id="PRO_0000209361"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  42650 MW;  BFCCD8B3417C9BB5 CRC64;
     MHNSPAAAAP KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP GMVGFFFTGS
     AVIGIIVSQF LAGRSDKKGD RKKLIVFCCV LGMLACVLFA WNRNYFILLF IGVFLSSFGS
     TANPQMFALA REHADRTGRE AVMFSSILRA QVSLAWVIGP PLAYALAMGF SFTVMYLSAA
     VAFIVCGVMV WFFLPSMRKD APLATGTLEA PRRNRRDTLL LFVICTLMWG TNSLYIINMP
     LFIINELHLP EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRLLMCIAVV AGLCFYVGML
     LAHAPATLLG LQLLNAIYIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTIR VGWIIAGSLA
     GIAAEIWNYH AVFWFALVMI VATMFCLARI KDV