SETC_ECOLI
ID SETC_ECOLI Reviewed; 394 AA.
AC P31436; Q2M7X1;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Sugar efflux transporter C;
GN Name=setC; Synonyms=yicK; OrderedLocusNames=b3659, JW3633;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT organizational symmetry around the origin of replication.";
RL Genomics 16:551-561(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION.
RX PubMed=10209755; DOI=10.1046/j.1365-2958.1999.01321.x;
RA Liu J.Y., Miller P.F., Gosink M., Olson E.R.;
RT "The identification of a new family of sugar efflux pumps in Escherichia
RT coli.";
RL Mol. Microbiol. 31:1845-1851(1999).
RN [5]
RP CHARACTERIZATION.
RX PubMed=10438463; DOI=10.1074/jbc.274.33.22977;
RA Liu J.Y., Miller P.F., Willard J., Olson E.R.;
RT "Functional and biochemical characterization of Escherichia coli sugar
RT efflux transporters.";
RL J. Biol. Chem. 274:22977-22984(1999).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC be the detoxification of non-metabolizable sugar analogs.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Set
CC transporter family. {ECO:0000305}.
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DR EMBL; L10328; AAA62011.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76682.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77635.1; -; Genomic_DNA.
DR PIR; D65167; D65167.
DR RefSeq; NP_418115.1; NC_000913.3.
DR RefSeq; WP_001172878.1; NZ_LN832404.1.
DR AlphaFoldDB; P31436; -.
DR SMR; P31436; -.
DR BioGRID; 4259628; 13.
DR STRING; 511145.b3659; -.
DR TCDB; 2.A.1.20.3; the major facilitator superfamily (mfs).
DR PaxDb; P31436; -.
DR PRIDE; P31436; -.
DR EnsemblBacteria; AAC76682; AAC76682; b3659.
DR EnsemblBacteria; BAE77635; BAE77635; BAE77635.
DR GeneID; 948177; -.
DR KEGG; ecj:JW3633; -.
DR KEGG; eco:b3659; -.
DR PATRIC; fig|1411691.4.peg.3047; -.
DR EchoBASE; EB1638; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_055598_3_0_6; -.
DR InParanoid; P31436; -.
DR OMA; PITYLQE; -.
DR PhylomeDB; P31436; -.
DR BioCyc; EcoCyc:B3659-MON; -.
DR PRO; PR:P31436; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0036448; P:cellular response to glucose-phosphate stress; IBA:GO_Central.
DR GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central.
DR GO; GO:0015767; P:lactose transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004750; Sugar_efflux.
DR PANTHER; PTHR23535:SF2; PTHR23535:SF2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00899; 2A0120; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..394
FT /note="Sugar efflux transporter C"
FT /id="PRO_0000209362"
FT TOPO_DOM 1..10
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..80
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..150
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..224
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..283
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..370
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 394 AA; 43493 MW; 310838BDFD04F92F CRC64;
MQKTATTPSK ILDLTAAAFL LVAFLTGIAG ALQTPTLSIF LADELKARPI MVGFFFTGSA
IMGILVSQFL ARHSDKQGDR KLLILLCCLF GVLACTLFAW NRNYFILLST GVLLSSFAST
ANPQMFALAR EHADRTGRET VMFSTFLRAQ ISLAWVIGPP LAYELAMGFS FKVMYLTAAI
AFVVCGLIVW LFLPSIQRNI PVVTQPVEIL PSTHRKRDTR LLFVVCSMMW AANNLYMINM
PLFIIDELHL TDKLTGEMIG IAAGLEIPMM LIAGYYMKRI GKRLLMLIAI VSGMCFYASV
LMATTPAVEL ELQILNAIFL GILCGIGMLY FQDLMPEKIG SATTLYANTS RVGWIIAGSV
DGIMVEIWSY HALFWLAIGM LGIAMICLLF IKDI
