ID   SETD6_DANRE             Reviewed;         460 AA.
AC   Q803K4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=N-lysine methyltransferase setd6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=setd6; ORFNames=zgc:55627;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; BC044440; AAH44440.1; -; mRNA.
DR   RefSeq; NP_955894.1; NM_199600.1.
DR   AlphaFoldDB; Q803K4; -.
DR   SMR; Q803K4; -.
DR   STRING; 7955.ENSDARP00000064572; -.
DR   PaxDb; Q803K4; -.
DR   GeneID; 322348; -.
DR   KEGG; dre:322348; -.
DR   CTD; 79918; -.
DR   ZFIN; ZDB-GENE-030131-1067; setd6.
DR   eggNOG; KOG1338; Eukaryota.
DR   InParanoid; Q803K4; -.
DR   OrthoDB; 490654at2759; -.
DR   PhylomeDB; Q803K4; -.
DR   Reactome; R-DRE-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q803K4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   CDD; cd19178; SET_SETD6; 1.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044430; SETD6_SET.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..460
FT                   /note="N-lysine methyltransferase setd6"
FT                   /id="PRO_0000281892"
FT   DOMAIN          28..265
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   460 AA;  53007 MW;  19681CEA8FD841A3 CRC64;
     MATEAKRPKT GDEKSVLEPL NNFLLWCESV QLTLSDKVYL SKEGTAAEYG MLAKEDIEEG
     HVLFTIPREA LLHQGTTKVK KVLEEGKKCL ESASGWVPLL LSLMYEYTSS TSHWKPYLSL
     WPDFRTLDQP MFWSEEECDK LLKGTGIPES VITDLRKLQD EYNSVVLPFM KSHPDLWDPE
     KHNLELYKSL VAFVMAYSFQ EPVEDDDEDE EDDEKKPNLP MMVPMADMLN HISKHNANLE
     YTPECLKMVS IRRIGKGEEV FNTYGQMANW QLLHMYGFAE PFPNNINETA DIKMASVYKA
     AAQVARSEAN QQLLEDKWKM LCEMEVVGEK GVFIFGQSGS LTYHELYTTL KVLCMSSQIF
     EDFRENEGWE EDDEDDDDKM EQDLSFEGLA SLSVEWKRLL CVAATETLDS YNEDVETDRR
     LMEDQRALAE LSSRERRALY VRLGQKNILQ RIQQLTKPAS