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SETD6_XENLA
ID   SETD6_XENLA             Reviewed;         455 AA.
AC   Q6INM2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=N-lysine methyltransferase setd6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=setd6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; BC072257; AAH72257.1; -; mRNA.
DR   RefSeq; NP_001085404.1; NM_001091935.1.
DR   AlphaFoldDB; Q6INM2; -.
DR   SMR; Q6INM2; -.
DR   MaxQB; Q6INM2; -.
DR   DNASU; 443830; -.
DR   GeneID; 443830; -.
DR   KEGG; xla:443830; -.
DR   CTD; 443830; -.
DR   Xenbase; XB-GENE-998238; setd6.L.
DR   OrthoDB; 490654at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 443830; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   CDD; cd19178; SET_SETD6; 1.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044430; SETD6_SET.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..455
FT                   /note="N-lysine methyltransferase setd6"
FT                   /id="PRO_0000281893"
FT   DOMAIN          38..266
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   455 AA;  52358 MW;  7972DAB7AC606D7A CRC64;
     MGPDAKKQKL EGVDHLQNGF PVTRFLAWCE KVGLELNPKV YISTEGTVSQ YGMLAREDIA
     DGELLFTVPR SAILSQNTTR IQELLEKEQE SLQSTSGWVP LLISLLYEAT DSSSLWAPYF
     GLWPELDPPD MPMFWSEEEQ TKLLQGTGVL EAIRNDLKNI EEEYNSIVLP FITRNPEKFC
     PMKHTLDLYK RLVAFVMAYS FQEPLEENDE EDEDEKDILP PMMVPVADLL NHVAHHNAHL
     EFTPECLRMV TTKSVHAGQE LFNTYGEMAN WQLLHMYGFA EPHPQNSNET ADIQMVTMRE
     AALQAAQTED DRLEMQKRWD FLCHIEMVGE EGAFVFGLEE VMTEEELKVS LKVLCMSKEE
     FAEYKENDGW EEDEGDDEQT LMIQEISHLP TPWRKLLHLS AKLTLKNYST ELSMDEALVN
     NITAYAKLSS REQRSLQVKY GQKRILHQLL ELTKS
 
 
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