SETD6_XENLA
ID SETD6_XENLA Reviewed; 455 AA.
AC Q6INM2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=N-lysine methyltransferase setd6;
DE EC=2.1.1.-;
DE AltName: Full=SET domain-containing protein 6;
GN Name=setd6;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein-lysine N-methyltransferase.
CC {ECO:0000250|UniProtKB:Q8TBK2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; BC072257; AAH72257.1; -; mRNA.
DR RefSeq; NP_001085404.1; NM_001091935.1.
DR AlphaFoldDB; Q6INM2; -.
DR SMR; Q6INM2; -.
DR MaxQB; Q6INM2; -.
DR DNASU; 443830; -.
DR GeneID; 443830; -.
DR KEGG; xla:443830; -.
DR CTD; 443830; -.
DR Xenbase; XB-GENE-998238; setd6.L.
DR OrthoDB; 490654at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 443830; Expressed in neurula embryo and 19 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR CDD; cd19178; SET_SETD6; 1.
DR Gene3D; 3.90.1420.10; -; 1.
DR InterPro; IPR011383; N-lys_methylase_SETD6.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044430; SETD6_SET.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF011771; RMS1_SET; 1.
DR SUPFAM; SSF81822; SSF81822; 1.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..455
FT /note="N-lysine methyltransferase setd6"
FT /id="PRO_0000281893"
FT DOMAIN 38..266
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ SEQUENCE 455 AA; 52358 MW; 7972DAB7AC606D7A CRC64;
MGPDAKKQKL EGVDHLQNGF PVTRFLAWCE KVGLELNPKV YISTEGTVSQ YGMLAREDIA
DGELLFTVPR SAILSQNTTR IQELLEKEQE SLQSTSGWVP LLISLLYEAT DSSSLWAPYF
GLWPELDPPD MPMFWSEEEQ TKLLQGTGVL EAIRNDLKNI EEEYNSIVLP FITRNPEKFC
PMKHTLDLYK RLVAFVMAYS FQEPLEENDE EDEDEKDILP PMMVPVADLL NHVAHHNAHL
EFTPECLRMV TTKSVHAGQE LFNTYGEMAN WQLLHMYGFA EPHPQNSNET ADIQMVTMRE
AALQAAQTED DRLEMQKRWD FLCHIEMVGE EGAFVFGLEE VMTEEELKVS LKVLCMSKEE
FAEYKENDGW EEDEGDDEQT LMIQEISHLP TPWRKLLHLS AKLTLKNYST ELSMDEALVN
NITAYAKLSS REQRSLQVKY GQKRILHQLL ELTKS