ID   SETD6_XENTR             Reviewed;         454 AA.
AC   A4QNG5;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=N-lysine methyltransferase setd6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=setd6;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; BC135640; AAI35641.1; -; mRNA.
DR   RefSeq; NP_001096520.1; NM_001103050.1.
DR   AlphaFoldDB; A4QNG5; -.
DR   SMR; A4QNG5; -.
DR   PaxDb; A4QNG5; -.
DR   DNASU; 100125156; -.
DR   GeneID; 100125156; -.
DR   KEGG; xtr:100125156; -.
DR   CTD; 79918; -.
DR   Xenbase; XB-GENE-998235; setd6.
DR   eggNOG; KOG1338; Eukaryota.
DR   HOGENOM; CLU_017135_2_0_1; -.
DR   InParanoid; A4QNG5; -.
DR   OMA; YGQLANW; -.
DR   OrthoDB; 490654at2759; -.
DR   PhylomeDB; A4QNG5; -.
DR   TreeFam; TF106399; -.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   CDD; cd19178; SET_SETD6; 1.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044430; SETD6_SET.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..454
FT                   /note="N-lysine methyltransferase setd6"
FT                   /id="PRO_0000405843"
FT   DOMAIN          38..265
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   454 AA;  52331 MW;  39B5A3DF16308A6B CRC64;
     MGPDAKKQKL QSEDHLQNDL PVSCFLAWCK KVGLELNPKV YISTEGTVSQ YGMLAREDLS
     DGELLFSIPR SAILSQNTTR IRDLIEKEQD SLQSCSGWVP LLISLLYEAT DSSSHWAPYF
     GLWPELDPPD MPMFWSEEEQ TKLLQGTGIL EAVHKDLKNI EKEYNSIVLP FIRRNPEKFC
     PMKHTLDLYK RLVAFVMAYS FQEPQEEDEE EDIEKDILPP MMVPVADLLN HVAQHNAHLE
     FTPECLRMIT TKSVCAGQEL FNTYGQMANW QLLHMYGFAE PHPQNCNETA DIQMVTVREA
     AFQVARTEED RLEMQKRWDF LCHIEIVGEE GAFVFGLEEV MTEEELKACL KVLCMSTDEF
     AEYKENDGWE EDEDNDEQTL LTQEISRLPI PWRKLLHLSA ELTLKAYKTE LSMDEALVND
     PTAYAKLSSR EQHSLQVQYG QKKILHLLLE LTKS