ID   SETD7_XENTR             Reviewed;         366 AA.
AC   Q4QQN5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Histone-lysine N-methyltransferase SETD7;
DE            EC=2.1.1.364 {ECO:0000250|UniProtKB:Q8WTS6, ECO:0000255|PROSITE-ProRule:PRU00910};
DE   AltName: Full=SET domain-containing protein 7;
GN   Name=setd7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone methyltransferase that specifically monomethylates
CC       'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag
CC       for epigenetic transcriptional activation. Plays a central role in the
CC       transcriptional activation of genes. Has also methyltransferase
CC       activity toward non-histone proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC         Evidence={ECO:0000250|UniProtKB:Q8WTS6, ECO:0000255|PROSITE-
CC         ProRule:PRU00910};
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00910}.
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DR   EMBL; BC098189; AAH98189.1; -; mRNA.
DR   RefSeq; NP_001027510.1; NM_001032339.1.
DR   AlphaFoldDB; Q4QQN5; -.
DR   SMR; Q4QQN5; -.
DR   STRING; 8364.ENSXETP00000036910; -.
DR   PaxDb; Q4QQN5; -.
DR   GeneID; 613102; -.
DR   KEGG; xtr:613102; -.
DR   CTD; 80854; -.
DR   Xenbase; XB-GENE-949196; setd7.
DR   eggNOG; KOG1079; Eukaryota.
DR   HOGENOM; CLU_803117_0_0_1; -.
DR   InParanoid; Q4QQN5; -.
DR   OMA; NGIRITH; -.
DR   OrthoDB; 675418at2759; -.
DR   PhylomeDB; Q4QQN5; -.
DR   TreeFam; TF106392; -.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q4QQN5; differential.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0070828; P:heterochromatin organization; IBA:GO_Central.
DR   GO; GO:0034968; P:histone lysine methylation; IEA:InterPro.
DR   GO; GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd10530; SET_SETD7; 1.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR017155; Hist-Lys_N-MeTrfase_SET.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044436; SETD7_SET.
DR   Pfam; PF02493; MORN; 3.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF037249; Histone_Lys_mtfrase_SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS51577; SAM_MT43_SET7; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Chromosome; Methyltransferase; Nucleus;
KW   Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN           1..366
FT                   /note="Histone-lysine N-methyltransferase SETD7"
FT                   /id="PRO_0000316991"
FT   REPEAT          36..58
FT                   /note="MORN 1"
FT   REPEAT          59..81
FT                   /note="MORN 2"
FT   REPEAT          106..128
FT                   /note="MORN 3"
FT   DOMAIN          214..336
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   BINDING         226..228
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00910"
FT   BINDING         294..297
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00910"
SQ   SEQUENCE   366 AA;  40816 MW;  9470B465CFFD2F4B CRC64;
     MDSEDETVEE TVEGLLDDDG LPHGFCTVNY SSTDRFEGHF VHGEKNGRGK FYFFDGSTLE
     GFYVDDALQG QGIYTYEDGG SLHGTYVEGE LNGPAQEYDT DGRLIFKGQY KDNVRHGVCW
     IYYPDGGSLV GEVNEDGDMT GDKVAYVYPD GRMALYGKFI DAEMLEGKLA ILTSVDEGKP
     HFELVPNGPV YNFDKSTPSC ISVNPLFPDP YESERVYVND SLIHNAGEGL FAKVASAAQT
     VMSFYNGVRI THQEVDSREW ALNGNTISLD DETVLDVPAP YNSYYKYCAS LGHKANHSFS
     PNCMYDTFVH PRFGPIKCIR TMKAVEKDEE LTVAYGYDHS VTGKNGPEAP EWYQQQLTAF
     QATQQK