SETH6_ARATH
ID SETH6_ARATH Reviewed; 635 AA.
AC O82253;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=BTB/POZ domain-containing protein SETH6;
GN Name=SETH6; OrderedLocusNames=At2g47860; ORFNames=F17A22.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=O82253-1; Sequence=Displayed;
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
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DR EMBL; AC005309; AAC63640.1; -; Genomic_DNA.
DR EMBL; AC006072; AAM15126.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10900.1; -; Genomic_DNA.
DR PIR; D84920; D84920.
DR RefSeq; NP_182307.1; NM_130353.3. [O82253-1]
DR AlphaFoldDB; O82253; -.
DR SMR; O82253; -.
DR STRING; 3702.AT2G47860.3; -.
DR iPTMnet; O82253; -.
DR PaxDb; O82253; -.
DR PRIDE; O82253; -.
DR ProteomicsDB; 234518; -. [O82253-1]
DR EnsemblPlants; AT2G47860.1; AT2G47860.1; AT2G47860. [O82253-1]
DR GeneID; 819398; -.
DR Gramene; AT2G47860.1; AT2G47860.1; AT2G47860. [O82253-1]
DR KEGG; ath:AT2G47860; -.
DR Araport; AT2G47860; -.
DR eggNOG; ENOG502QSDZ; Eukaryota.
DR HOGENOM; CLU_005994_6_0_1; -.
DR InParanoid; O82253; -.
DR PhylomeDB; O82253; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:O82253; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O82253; baseline and differential.
DR Genevisible; O82253; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Phosphoprotein; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..635
FT /note="BTB/POZ domain-containing protein SETH6"
FT /id="PRO_0000409568"
FT DOMAIN 39..104
FT /note="BTB"
FT DOMAIN 206..494
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 604..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 435
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ SEQUENCE 635 AA; 70998 MW; 56416DE8F4D0D6CC CRC64;
MGVVTVPESN KQSVAAKRAF RPSSSIRHTP QWPVSDVTSD LTIEVGSATF SLHKFPLVSR
SGRIRKLVLE SKDTNLNLAA VPGGSESFEL AAKFCYGVGV QYNSSNIAAL RCVAHYLEMT
EDLSEKNLEA RTEAYLKDSI FNDISNSITV LHSCERLLPV AEEINLVGRL VNAIAVNACK
EQLASGLLKL DQSFSCGVPE TAKPCDWWGR SLPILKLDFF QRVLSAMKSK GLNHDIISDI
LMSYARKSLQ IIREPNLVKS DSDLQRKQRI VLEAVVGLLP TQANKSSIPI SFLSSLLKTA
IGSGTSVSCR SDLERRISHL LDQAILEDIL IPANIGAMYD TDSVQRIFSM FLNLDECEYR
DDDDDEEDAV DESEMAMYDF EGAESPKQSS IFKVSKLMDS YLAEVALDSS LPPSKFIALA
ELLPDHARVV CDGLYRAVDI FLKVHPHMKD SERYRLCKTV SCKKLSQDAS SHAAQNERLP
VQIAVQVLFY EQTRLKNAMT SGGGTGGSNQ SQFFLFPNRS GSGMASGAIS PRDNYASVRR
ENRELRLEVA RMRMRLTDLE KDHVSMKRDF VKPQSRRRRY GMLRKLSRGL NKLNAIVLRF
RSSQSVASSG KKHTEEKTNS ERRFMFQKRR CHSVS
