SEU1_CAEEL
ID SEU1_CAEEL Reviewed; 672 AA.
AC A9D2P7; H2L0L8; H2L0L9; Q8IU02; V6CLR5;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protein seu-1 {ECO:0000305};
DE AltName: Full=Suppressor of ectopic unc-5 {ECO:0000312|WormBase:Y73B6BL.5d};
GN Name=seu-1 {ECO:0000312|WormBase:Y73B6BL.5d};
GN ORFNames=Y73B6BL.5 {ECO:0000312|WormBase:Y73B6BL.5d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF 191-ARG--LEU-672.
RX PubMed=9473333; DOI=10.1006/dbio.1997.8790;
RA Colavita A., Culotti J.G.;
RT "Suppressors of ectopic UNC-5 growth cone steering identify eight genes
RT involved in axon guidance in Caenorhabditis elegans.";
RL Dev. Biol. 194:72-85(1998).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF 191-ARG--LEU-672 AND 630-GLN--LEU-672.
RX PubMed=17716643; DOI=10.1016/j.ydbio.2007.07.014;
RA Zheng H., Coudiere L., Camia C., Colavita A., Culotti J.G., Merz D.C.;
RT "C. elegans seu-1 encodes novel nuclear proteins that regulate responses to
RT UNC-6/netrin guidance cues.";
RL Dev. Biol. 310:44-53(2007).
CC -!- FUNCTION: Together with unc-5, involved in touch neuron axon guidance
CC (PubMed:9473333). During gonad morphogenesis, plays a role in the unc-
CC 5-/unc-6-mediated migration of distal tip cells along the body
CC (PubMed:17716643). {ECO:0000269|PubMed:17716643,
CC ECO:0000269|PubMed:9473333}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17716643}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=d {ECO:0000312|WormBase:Y73B6BL.5d}; Synonyms=seu-1A
CC {ECO:0000303|PubMed:17716643};
CC IsoId=A9D2P7-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:Y73B6BL.5a}; Synonyms=seu-1B
CC {ECO:0000303|PubMed:17716643};
CC IsoId=A9D2P7-2; Sequence=VSP_061194, VSP_061195;
CC Name=b {ECO:0000312|WormBase:Y73B6BL.5b};
CC IsoId=A9D2P7-3; Sequence=VSP_061193, VSP_061194, VSP_061195;
CC Name=c {ECO:0000312|WormBase:Y73B6BL.5c};
CC IsoId=A9D2P7-4; Sequence=VSP_061192, VSP_061194, VSP_061195;
CC Name=e {ECO:0000312|WormBase:Y73B6BL.5e};
CC IsoId=A9D2P7-5; Sequence=VSP_061192, VSP_061195;
CC -!- TISSUE SPECIFICITY: Highly expressed in intestinal cells, lateral
CC hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca
CC (PubMed:17716643). Expressed at low levels in the ventral nerve cord
CC (PubMed:17716643). {ECO:0000269|PubMed:17716643}.
CC -!- DEVELOPMENTAL STAGE: Expressed in all nuclei in the early embryo until
CC the comma stage, and then is expressed in body wall muscle cells and
CC pharynx in the embryo (PubMed:17716643). Expressed in muscle until the
CC late larval stages (PubMed:17716643). In larvae, highly expressed in
CC intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral
CC hypodermal cells, and spermatheca (PubMed:17716643). In L3 stage
CC larvae, expressed at low levels in distal tip cells during the ventral-
CC to-dorsal second and longitudinal third migration phases, but not
CC expressed during the first migration phase (PubMed:17716643). In L4
CC stage larvae, expressed at low levels in the ventral nerve cord
CC (PubMed:17716643). {ECO:0000269|PubMed:17716643}.
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DR EMBL; BX284604; CCD74152.1; -; Genomic_DNA.
DR EMBL; BX284604; CCD74153.1; -; Genomic_DNA.
DR EMBL; BX284604; CCD74154.1; -; Genomic_DNA.
DR EMBL; BX284604; CCD74193.1; -; Genomic_DNA.
DR EMBL; BX284604; CDK13502.1; -; Genomic_DNA.
DR RefSeq; NP_001293775.1; NM_001306846.1.
DR RefSeq; NP_500965.1; NM_068564.4. [A9D2P7-2]
DR RefSeq; NP_500966.1; NM_068565.5. [A9D2P7-3]
DR RefSeq; NP_741420.1; NM_171358.3.
DR RefSeq; NP_741421.2; NM_171359.3. [A9D2P7-1]
DR AlphaFoldDB; A9D2P7; -.
DR STRING; 6239.Y73B6BL.5d.2; -.
DR EPD; A9D2P7; -.
DR PaxDb; A9D2P7; -.
DR EnsemblMetazoa; Y73B6BL.5a.1; Y73B6BL.5a.1; WBGene00004783. [A9D2P7-2]
DR EnsemblMetazoa; Y73B6BL.5b.1; Y73B6BL.5b.1; WBGene00004783. [A9D2P7-3]
DR EnsemblMetazoa; Y73B6BL.5c.1; Y73B6BL.5c.1; WBGene00004783. [A9D2P7-4]
DR EnsemblMetazoa; Y73B6BL.5d.1; Y73B6BL.5d.1; WBGene00004783. [A9D2P7-1]
DR EnsemblMetazoa; Y73B6BL.5e.1; Y73B6BL.5e.1; WBGene00004783. [A9D2P7-5]
DR GeneID; 177394; -.
DR KEGG; cel:CELE_Y73B6BL.5; -.
DR UCSC; Y73B6BL.5d.1; c. elegans.
DR CTD; 177394; -.
DR WormBase; Y73B6BL.5a; CE29147; WBGene00004783; seu-1. [A9D2P7-2]
DR WormBase; Y73B6BL.5b; CE29148; WBGene00004783; seu-1. [A9D2P7-3]
DR WormBase; Y73B6BL.5c; CE31129; WBGene00004783; seu-1. [A9D2P7-4]
DR WormBase; Y73B6BL.5d; CE41963; WBGene00004783; seu-1. [A9D2P7-1]
DR WormBase; Y73B6BL.5e; CE49209; WBGene00004783; seu-1. [A9D2P7-5]
DR eggNOG; ENOG502TGB7; Eukaryota.
DR HOGENOM; CLU_028920_0_0_1; -.
DR InParanoid; A9D2P7; -.
DR OMA; WCALLAC; -.
DR OrthoDB; 1799806at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004783; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; A9D2P7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0033563; P:dorsal/ventral axon guidance; IGI:WormBase.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..672
FT /note="Protein seu-1"
FT /id="PRO_0000453731"
FT REGION 1..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..339
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..180
FT /note="Missing (in isoform c and isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_061192"
FT VAR_SEQ 88..132
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061193"
FT VAR_SEQ 461..576
FT /note="Missing (in isoform a, isoform b and isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061194"
FT VAR_SEQ 665..672
FT /note="VSLSLKHL -> RRRPSPPRGRPGEKVVQSYRNGV (in isoform a,
FT isoform b, isoform c and isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_061195"
FT MUTAGEN 191..672
FT /note="Missing: In ev520; mild uncoordinated phenotype.
FT Causes no axon guidance defects or distal tip cell
FT migrations and gonad morphology defects. Enhances the
FT distal tip cell migration defects of unc-5 ev585, unc-5 e53
FT or unc-6 ev400 mutants. Suppresses the anterior touch
FT neuron axon guidance defects in an unc-5 over-expression
FT mutant background."
FT /evidence="ECO:0000269|PubMed:17716643,
FT ECO:0000269|PubMed:9473333"
FT MUTAGEN 630..672
FT /note="Missing: In ev529; causes no distal tip cell
FT migrations and gonad morphology defects. Enhances the
FT distal tip cell migration defects of the unc-5 ev585, unc-5
FT e53 or unc-6 ev400 mutants."
FT /evidence="ECO:0000269|PubMed:17716643"
SQ SEQUENCE 672 AA; 75388 MW; E69F422D91F7C5A8 CRC64;
MSSIRNQNDN RRPTFRDHRT PQFSGRGGSG GGGRRLQNPA HYPQRRDMSP IRRSSAISPV
RRSQDHRQRS PEVRRHRSPE KESKDAVVTS TGSSRGATSA SVTSSSRRHE SGERHRETHR
REDKEKKPEK STDRDADRSN NIAARIQAPV VSSSTHHHHS NRHENRKSTA VKRPAADNRP
MTYSTDVSVS RHSENRRKSS SDVSRRHGDK EKRDRKREDV KKKSNGERSS SSGRRREEDH
KRKSESSRKE KKDEDVKEKV VDENKVEDEA VEMQGLVEVD CCEEEETIEQ AKEHGSDEPE
RPESHQSAHS AAVSNASHHS DSEEELDYEE DDIDVDLDGD IDVETMKMAA RGDLKVDDTT
DEDEINDVKD ETMEEQKEDG EPEKKKPRTS ENDDKDKKHH GSSSSNSHRR REDDKDRRQS
SDHHKERRRS PATRQRATDH KESRRSEGTS TRVESAASAA GTEIQRIPSL LTMRIAAPPG
IKKLETLYHS GSGGSSSSSS HSSEMIIVGE TFSNRWCQCS CAHHLPTTSS AAAAAGSLDA
SPASSSSSSS NSDASVSRIP SLMSLRTPFN NSCLFLAPPP PPSSSSSSKR SHEAAARIRA
PSPPRRSFGD RGNRSDEHHG GSRHMDVGPQ RRRLQDHRVR DDGRRVSSFE DRKRPERGFQ
DSGRVSLSLK HL
