SEUSS_ARATH
ID SEUSS_ARATH Reviewed; 877 AA.
AC Q8W234; Q8GXE8; Q9MAR3;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Transcriptional corepressor SEUSS;
DE Short=AtSEU;
GN Name=SEU; OrderedLocusNames=At1g43850; ORFNames=F28H19.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC STRAIN=cv. Columbia; TISSUE=Root;
RX PubMed=11782418; DOI=10.1242/dev.129.1.253;
RA Franks R.G., Wang C., Levin J.Z., Liu Z.;
RT "SEUSS, a member of a novel family of plant regulatory proteins, represses
RT floral homeotic gene expression with LEUNIG.";
RL Development 129:253-263(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 586-877.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH LUG.
RX PubMed=15277686; DOI=10.1073/pnas.0403055101;
RA Sridhar V.V., Surendrarao A., Gonzalez D., Conlan R.S., Liu Z.;
RT "Transcriptional repression of target genes by LEUNIG and SEUSS, two
RT interacting regulatory proteins for Arabidopsis flower development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11494-11499(2004).
RN [6]
RP FUNCTION, INTERACTION WITH AP1 AND SEP3, AND DISRUPTION PHENOTYPE.
RX PubMed=16854969; DOI=10.1242/dev.02498;
RA Sridhar V.V., Surendrarao A., Liu Z.;
RT "APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription
RT repression during flower development.";
RL Development 133:3159-3166(2006).
RN [7]
RP FUNCTION.
RX PubMed=16625397; DOI=10.1007/s00425-006-0264-6;
RA Franks R.G., Liu Z., Fischer R.L.;
RT "SEUSS and LEUNIG regulate cell proliferation, vascular development and
RT organ polarity in Arabidopsis petals.";
RL Planta 224:801-811(2006).
RN [8]
RP INTERACTION WITH LUG; AGL24-AP1 AND SVP-AP1.
RX PubMed=16679456; DOI=10.1105/tpc.106.041798;
RA Gregis V., Sessa A., Colombo L., Kater M.M.;
RT "AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS
RT during early stages of flower development in Arabidopsis.";
RL Plant Cell 18:1373-1382(2006).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=18184731; DOI=10.1104/pp.107.114751;
RA Azhakanandam S., Nole-Wilson S., Bao F., Franks R.G.;
RT "SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during
RT gynoecium medial domain development.";
RL Plant Physiol. 146:1165-1181(2008).
RN [10]
RP INTERACTION WITH LUH, TISSUE SPECIFICITY, AND INDUCTION BY BIOTIC AND
RP ABIOTIC STRESSES.
RX PubMed=18390806; DOI=10.1104/pp.108.115923;
RA Sitaraman J., Bui M., Liu Z.;
RT "LEUNIG_HOMOLOG and LEUNIG perform partially redundant functions during
RT Arabidopsis embryo and floral development.";
RL Plant Physiol. 147:672-681(2008).
RN [11]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20007451; DOI=10.1104/pp.109.146183;
RA Bao F., Azhakanandam S., Franks R.G.;
RT "SEUSS and SEUSS-LIKE transcriptional adaptors regulate floral and
RT embryonic development in Arabidopsis.";
RL Plant Physiol. 152:821-836(2010).
CC -!- FUNCTION: DNA-binding adapter subunit of the SEU-LUG transcriptional
CC corepressor of the C class floral homeotic gene AGAMOUS during the
CC early stages of floral meristem development. Is part of the A class
CC cadastral complex that define the boundaries between the A and C class
CC homeotic genes expression and function. Interacts together with
CC APETALA2 and LEUNIG to repress AGAMOUS expression. In association with
CC LUG, regulates petal shape through AGAMOUS-independent mechanisms.
CC Controls cell division during petal development and enable the proper
CC patterning of petal blade vasculature. Required for the proper
CC elaboration of petal polarity along the adaxial/abaxial axis. May act
CC through direct or indirect regulation of PHABULOSA and YAB1 and thus
CC regulate cellular proliferation within the developing petal blade. In
CC association with AINTEGUMENTA (ANT), coordinates patterning cues and
CC cellular proliferation along the three positional axes of the
CC developing gynoecium. Required for the development of the medial ridge
CC and subsequent ovule initiation. {ECO:0000269|PubMed:15277686,
CC ECO:0000269|PubMed:16625397, ECO:0000269|PubMed:16854969,
CC ECO:0000269|PubMed:18184731, ECO:0000269|PubMed:20007451}.
CC -!- SUBUNIT: Forms a corepressor complex with LUG; LUG is the transcription
CC repressor subunit and SEU the specific DNA-binding adapter. Interacts
CC with AGL24-AP1 and SVP-AP1 dimers when complexed to SEU. Interacts with
CC AP1/AGL7 and SEP3/AGL9 (PubMed:15277686, PubMed:16679456,
CC PubMed:16854969). Binds to LUH (PubMed:18390806).
CC {ECO:0000269|PubMed:15277686, ECO:0000269|PubMed:16679456,
CC ECO:0000269|PubMed:16854969, ECO:0000269|PubMed:18390806}.
CC -!- INTERACTION:
CC Q8W234; P35631: AP1; NbExp=2; IntAct=EBI-1771131, EBI-592003;
CC Q8W234; Q9FUY2: LUG; NbExp=6; IntAct=EBI-1771131, EBI-1771115;
CC Q8W234; O22456: SEP3; NbExp=2; IntAct=EBI-1771131, EBI-592020;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:18184731}. Note=Does not localize in the nucleolus.
CC -!- TISSUE SPECIFICITY: Expressed in root, leaves, seedlings, vegetative
CC and reproductive shoot apical meristems, seeds, floral meristems and
CC all floral organs. {ECO:0000269|PubMed:18184731,
CC ECO:0000269|PubMed:18390806}.
CC -!- INDUCTION: Induced by exposures to biotic stress (e.g. nematode and
CC Botrytis cinerea) and abiotic stress (e.g. salt, genotoxic, wounding,
CC drought and oxidative stress). Repressed by exposures to biotic stress
CC (e.g. Agrobacterium tumefaciens) and abiotic stress (e.g. hypoxia,
CC cycloheximide, 2,4-dichlorophenoxyacetic acid, AgNO(3) and
CC aminoethoxyvinylglycine). {ECO:0000269|PubMed:18390806}.
CC -!- DOMAIN: Contains a dimerization domain which shares similarity with the
CC LIM-binding domain of animal transcription coregulators.
CC -!- DISRUPTION PHENOTYPE: Ectopic and precocious expression of AGAMOUS,
CC leading to partial homeotic transformation of the external floral
CC organs. {ECO:0000269|PubMed:15277686, ECO:0000269|PubMed:16854969,
CC ECO:0000269|PubMed:20007451}.
CC -!- SIMILARITY: Belongs to the adn1/SEU family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF63115.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF378782; AAL57277.1; -; mRNA.
DR EMBL; AC006423; AAF63115.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32000.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32001.1; -; Genomic_DNA.
DR EMBL; AK118277; BAC42895.1; -; mRNA.
DR PIR; D96502; D96502.
DR RefSeq; NP_001117434.1; NM_001123962.2.
DR RefSeq; NP_175051.1; NM_103511.4.
DR AlphaFoldDB; Q8W234; -.
DR BioGRID; 26206; 6.
DR IntAct; Q8W234; 3.
DR STRING; 3702.AT1G43850.1; -.
DR iPTMnet; Q8W234; -.
DR MetOSite; Q8W234; -.
DR PaxDb; Q8W234; -.
DR PRIDE; Q8W234; -.
DR ProteomicsDB; 234489; -.
DR EnsemblPlants; AT1G43850.1; AT1G43850.1; AT1G43850.
DR EnsemblPlants; AT1G43850.2; AT1G43850.2; AT1G43850.
DR GeneID; 840981; -.
DR Gramene; AT1G43850.1; AT1G43850.1; AT1G43850.
DR Gramene; AT1G43850.2; AT1G43850.2; AT1G43850.
DR KEGG; ath:AT1G43850; -.
DR Araport; AT1G43850; -.
DR TAIR; locus:2029137; AT1G43850.
DR eggNOG; ENOG502QTWZ; Eukaryota.
DR HOGENOM; CLU_007007_0_0_1; -.
DR InParanoid; Q8W234; -.
DR OMA; PGAGMVQ; -.
DR OrthoDB; 583558at2759; -.
DR PhylomeDB; Q8W234; -.
DR PRO; PR:Q8W234; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8W234; baseline and differential.
DR Genevisible; Q8W234; AT.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:TAIR.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB.
DR GO; GO:0071217; P:cellular response to external biotic stimulus; IDA:UniProtKB.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0048467; P:gynoecium development; IMP:TAIR.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048481; P:plant ovule development; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009909; P:regulation of flower development; IGI:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; IEP:UniProtKB.
DR GO; GO:0046898; P:response to cycloheximide; IEP:UniProtKB.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR GO; GO:0001666; P:response to hypoxia; IEP:UniProtKB.
DR GO; GO:0009624; P:response to nematode; IEP:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IEP:UniProtKB.
DR GO; GO:0010272; P:response to silver ion; IEP:UniProtKB.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR Pfam; PF01803; LIM_bind; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Differentiation; Flowering; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..877
FT /note="Transcriptional corepressor SEUSS"
FT /id="PRO_0000097700"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..563
FT /note="Dimerization"
FT REGION 560..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 582..618
FT /evidence="ECO:0000255"
FT MOTIF 330..344
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 272..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 96232 MW; 636D83BAD3946467 CRC64;
MVPSEPPNPV GGGENVPPSI LGGQGGAPLP SQPAFPSLVS PRTQFGNNMS MSMLGNAPNI
SSLLNNQSFV NGIPGSMISM DTSGAESDPM SNVGFSGLSS FNASSMVSPR SSGQVQGQQF
SNVSANQLLA EQQRNKKMET QSFQHGQQQS MQQQFSTVRG GGLAGVGPVK MEPGQVSNDQ
QHGQVQQQQQ KMLRNLGSVK LEPQQIQAMR NLAQVKMEPQ HSEQSLFLQQ QQRQQQQQQQ
QQFLQMPGQS PQAQMNIFQQ QRLMQLQQQQ LLKSMPQQRP QLPQQFQQQN LPLRPPLKPV
YEPGMGAQRL TQYMYRQQHR PEDNNIEFWR KFVAEYFAPN AKKRWCVSMY GSGRQTTGVF
PQDVWHCEIC NRKPGRGFEA TAEVLPRLFK IKYESGTLEE LLYVDMPRES QNSSGQIVLE
YAKATQESVF EHLRVVRDGQ LRIVFSPDLK IFSWEFCARR HEELIPRRLL IPQVSQLGSA
AQKYQQAAQN ATTDSALPEL QNNCNMFVAS ARQLAKALEV PLVNDLGYTK RYVRCLQISE
VVNSMKDLID YSRETRTGPI ESLAKFPRRT GPSSALPGPS PQQASDQLRQ QQQQQQQQQQ
QQQQQQQQQQ QQQTVSQNTN SDQSSRQVAL MQGNPSNGVN YAFNAASAST STSSIAGLIH
QNSMKGRHQN AAYNPPNSPY GGNSVQMQSP SSSGTMVPSS SQQQHNLPTF QSPTSSSNNN
NPSQNGIPSV NHMGSTNSPA MQQAGEVDGN ESSSVQKILN EILMNNQAHN NSSGGSMVGH
GSFGNDGKGQ ANVNSSGVLL MNGQVNNNNN TNIGGAGGFG GGIGQSMAAN GINNINGNNS
LMNGRVGMMV RDPNGQQDLG NQLLGAVNGF NNFDWNA
