ID   SEX3_MYCLE              Reviewed;         443 AA.
AC   P54883; Q9CB51;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Sensor-like histidine kinase SenX3;
DE            EC=2.7.13.3;
GN   Name=senX3; OrderedLocusNames=ML2440; ORFNames=B2168_C3_247;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Probably forms part of a two-component regulatory system
CC       SenX3/RegX3. Phosphorylates RegX3 (Probable). {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC31957.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U00018; AAA17241.1; -; Genomic_DNA.
DR   EMBL; AL583925; CAC31957.1; ALT_INIT; Genomic_DNA.
DR   PIR; E87214; E87214.
DR   PIR; S72905; S72905.
DR   RefSeq; WP_010908900.1; NC_002677.1.
DR   AlphaFoldDB; P54883; -.
DR   SMR; P54883; -.
DR   STRING; 272631.ML2440; -.
DR   PRIDE; P54883; -.
DR   EnsemblBacteria; CAC31957; CAC31957; CAC31957.
DR   KEGG; mle:ML2440; -.
DR   Leproma; ML2440; -.
DR   eggNOG; COG5002; Bacteria.
DR   HOGENOM; CLU_000445_89_2_11; -.
DR   BRENDA; 2.7.13.3; 3504.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..443
FT                   /note="Sensor-like histidine kinase SenX3"
FT                   /id="PRO_0000074875"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          164..380
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         167
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   443 AA;  47967 MW;  3951C1F5CD6731BB CRC64;
     MTVFSALLLA GVLSGLAFVV GIVAGIRLSP RLIERRQRLA NEWAGITVLQ MLQRIIALMP
     LGAAVVDTYR DVVYLNEQAK ELGLVRDRQL DDQAWRAAQQ ALGGDDVEFD LLPGKRPAAG
     RSGLSVHGHA RLLSEKDRRF AVVFVHDQSD YVRMEAARRD FVANVSHELK TPVGAMALLA
     EALLASADDA ETVSRFAEKV LIEANRLGYM VAELIELSRL QGAERLPNVT DIDVDIIVSE
     AIARHKVAAD TAAIEVRTDP PSGLRVLGDQ TLLVTALANL VSNAIAYSPG GSLVSISRRR
     RGDNIEIAVT DRGIGIALED QERVFERFFR GDKARSRATG GSGLGLAIVK HVAANHNGSI
     GVWSKPGTGS TFTLSIPAAM PLYQDNDEQS GQPRGCDMWL NRPQREEEEF KSMTPAQAMM
     QSEVTRGNVN DKCPDCGGRG IAG