SEY11_ENTHI
ID SEY11_ENTHI Reviewed; 959 AA.
AC C4LTM1;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Protein SEY1 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN ORFNames=EHI_012280;
OS Entamoeba histolytica.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=5759;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30459 / HM-1:IMSS;
RX PubMed=15729342; DOI=10.1038/nature03291;
RA Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P.,
RA Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M.,
RA Duchene M., Ackers J., Tannich E., Leippe M., Hofer M., Bruchhaus I.,
RA Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z.,
RA Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D.,
RA Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H.,
RA Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S.,
RA Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U.,
RA Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M.,
RA Barrell B.G., Fraser C.M., Hall N.;
RT "The genome of the protist parasite Entamoeba histolytica.";
RL Nature 433:865-868(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 30459 / HM-1:IMSS;
RA Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC development. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR EMBL; DS571148; EAL49849.2; -; Genomic_DNA.
DR RefSeq; XP_655238.2; XM_650146.2.
DR AlphaFoldDB; C4LTM1; -.
DR SMR; C4LTM1; -.
DR STRING; 5759.rna_EHI_012280-1; -.
DR GeneID; 3409540; -.
DR KEGG; ehi:EHI_012280; -.
DR VEuPathDB; AmoebaDB:EHI5A_093900; -.
DR VEuPathDB; AmoebaDB:EHI7A_106310; -.
DR VEuPathDB; AmoebaDB:EHI8A_067450; -.
DR VEuPathDB; AmoebaDB:EHI_012280; -.
DR VEuPathDB; AmoebaDB:KM1_122850; -.
DR eggNOG; KOG2203; Eukaryota.
DR InParanoid; C4LTM1; -.
DR OMA; TNFDVMD; -.
DR Proteomes; UP000001926; Partially assembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR PANTHER; PTHR45923; PTHR45923; 1.
DR Pfam; PF05879; RHD3; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..959
FT /note="Protein SEY1 homolog 1"
FT /id="PRO_0000384946"
FT TOPO_DOM 1..767
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 789..791
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 792..812
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 813..959
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT DOMAIN 123..340
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT REGION 62..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..86
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT BINDING 133..140
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ SEQUENCE 959 AA; 112118 MW; A437CBC391357C41 CRC64;
MQESDVFHNQ LRVEMLKKEE DEVENNSEKK KAPGIDMNKV NLIKTRDEDI IAENIKAELK
EEEKENMKVE EEEIKEEEEK KEKENYPCMQ IIDQEGIFAD ENQKDRITFE EFIQENTKFK
ELGFNYNMLS ILGPQNSGKS TLLNYLFDTD FAVLNEKNGR QRTTRGVWLG LVGDRKDIII
MDLEGSDGSI REDDLSFERK ISLFSLSVCS VLMVNIWSHD VGRYGASNMS LLKNIFELNL
QLFQKEDSPK TLILFVIRDR DQRKPFENTK SVLLEDIMKI WESVARPECF KRAPIDKFFD
LEFTSLPHFK HDKELFIQEA KELKKRFDCK NQNTYFRPIY NKEIPADGLA LFTKQVWSAI
KSNKDLDLPS QKEMLARFRC DELIENIFNE FEKEIEEIKL QHSEKHIFNN FKIFCDCLYD
KKMKEFMNVA SKYLDRVVKE KADLLSEKML NEISYLFQTQ MTLAINYIKT MLTTSYFTLK
NQYITEQSSL FDPTKYAGYA EQMDDFNSTI KNEWEKISTQ SVPSNIENNF EIEINTLDRF
INKLYEIGRR DLIEALMTHF KKHLQNIMKP LLLPLFEQSN QNMWEQVRKV VIETTSQNLQ
ELENGMINSL KMNKDDVEKK LNELQVYIID AVRSTILERP GFVSNLMENK FISIFRLDDE
GLPKKWKQNE DLSKPFFKAK EEAEKILDLF SYIRMDPKDD ELSFISINPA TGKKMIIEEP
ENGTIDQTKV LFSLSERLSI YEGFQNMAES NFIRAQQELA AITVHSKTPM WLILLIAFLS
FDNIVYVFKS PTLLALTLII IGIIYSLNKI GYAYLIDSVI SYILSISWSS VLYLIQDLGL
FKNLLPKPEA PKRKRPQKKT QDDKPKSSIL LTHKKQPSVM GDVTMDNIDS LNSFDDAFKL
VSQDEKPIRK PLHPLPKRET QSMKVMPMSA SFTKSQSMFI KRNPTTTSSL NKIKEANEF
