SEY11_TRIVA
ID SEY11_TRIVA Reviewed; 804 AA.
AC A2EI35;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Protein SEY1 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN ORFNames=TVAG_273580;
OS Trichomonas vaginalis.
OC Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC Trichomonas.
OX NCBI_TaxID=5722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-98 / G3;
RX PubMed=17218520; DOI=10.1126/science.1132894;
RA Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S.,
RA Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D.,
RA Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y.,
RA Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M.,
RA Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J.,
RA Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B.,
RA Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A.,
RA Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S.,
RA Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA Johnson P.J.;
RT "Draft genome sequence of the sexually transmitted pathogen Trichomonas
RT vaginalis.";
RL Science 315:207-212(2007).
CC -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC development. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR EMBL; DS113394; EAY07674.1; -; Genomic_DNA.
DR RefSeq; XP_001319897.1; XM_001319862.1.
DR AlphaFoldDB; A2EI35; -.
DR SMR; A2EI35; -.
DR STRING; 5722.XP_001319897.1; -.
DR PRIDE; A2EI35; -.
DR GeneID; 4765569; -.
DR KEGG; tva:TVAG_273580; -.
DR VEuPathDB; TrichDB:TVAG_273580; -.
DR eggNOG; KOG2203; Eukaryota.
DR InParanoid; A2EI35; -.
DR OMA; TNFDVMD; -.
DR Proteomes; UP000001542; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR PANTHER; PTHR45923; PTHR45923; 1.
DR Pfam; PF05879; RHD3; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..804
FT /note="Protein SEY1 homolog 1"
FT /id="PRO_0000384960"
FT TOPO_DOM 1..638
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 660..662
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 684..804
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT DOMAIN 28..245
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT REGION 706..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 38..45
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ SEQUENCE 804 AA; 92417 MW; CF1459A3107DBF6E CRC64;
MEQIITGEGQ IVPDLDEHIT RSGIDQAGTD YHMVSIIGCQ SSGKSTLLNL LFGTKFETMN
EQKGRQQTTK GIHAARAVNG PILLFDVEGS DSRERGDSDA LFERKSSLFA LALSELLVIN
MWESDIGRYN AANIPMLKTV MEVNVQLFLA QSTSKSKILF VIRDSTIPNF DVIKFQINRD
MENIWAEITL PDSLKDKTIH DFFDFDFYAI HHMVIQRDIF DKDISALRQR FIDEKEENYL
FKEKSTKVVP GGGLSTYIRN LWEVINENKE LNIPSQKLML SRFKCEENAK AAYDQFKEKV
TKTILEPMAD ESVNLGDKFK SNAEEAIKAA NKFYHDNSWR YQQAAVEEFQ QKLSTDIGDL
LISYYIKHCN YYARQVMQEF TKFISGLPDS FEKGGKWAIE VQAKIDELSL RLDSTCRDSL
IEGYKWQFPS FKTIKAMDDA RKSYEEIMTK KLYKNIFAEE KIAFDDKASE LLMIADQNMW
ENLRKLIEAS AKVTDDRFME IIKTNVLNPK PQEGTLKRFQ RHALNIVKES ANYIMMKMKT
AFDRSFRYEK NGRPRVWTRR HNLNQIYEES RASGRKVLIL FTYCRLASPD DQTPNNPLNQ
VLIPVEKSQE IEEKFEKLII HAYEEARASV LASQNNEHIP PWAWFLFLFS CSDYILWWLS
NPLLFSLTVL FGGTYLVLNQ LGLWDTAVQK LLDIIKKKIV ELGATPDENN ETETNQTIPV
EESQITPPPP TETTTDDGPV MKRRVHRSKA QGLTKTESNV TFANVSNAND EQSLTKNNTE
DSLNTGSSSS GQRHRKRVRV GTLV
