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SEY1_ASPOR
ID   SEY1_ASPOR              Reviewed;         860 AA.
AC   Q2UNK6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein sey1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   Name=sey1; ORFNames=AO090001000326;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Cooperates with the reticulon proteins and tubule-shaping DP1
CC       family proteins to generate and maintain the structure of the tubular
CC       endoplasmic reticulum network. Has GTPase activity, which is required
CC       for its function in ER organization. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER.
CC       Concentrated in punctae along the ER tubules. {ECO:0000255|HAMAP-
CC       Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE56859.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007154; BAE56859.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2UNK6; -.
DR   SMR; Q2UNK6; -.
DR   STRING; 510516.Q2UNK6; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:EnsemblFungi.
DR   GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..860
FT                   /note="Protein sey1"
FT                   /id="PRO_0000384973"
FT   TOPO_DOM        1..742
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        743..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        764..766
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        767..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        788..860
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          51..300
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   REGION          818..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          443..501
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         61..68
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   860 AA;  96683 MW;  BCBBAC895CC7D234 CRC64;
     MATNGHFASI GNSASDTTAY EHGVQVIDEN KEFKNPNLSQ YLSLENVTPS GFNYHLISVF
     GSQSTGKSTL LNHLFGTHFS VMSELERRQT TKGIWMSKNK NESSSMASNI LVMDVEGTDG
     RERGEDQDFE RKSALFALAT SEVLIVNIWE HQVGLYQGAN MGLLKTVFEV NLQLFLKDKN
     TTHRSLLFFV IRDYSGMTPL QNLQKTLMED MARLWDSISK PGGLENSNVH DYFDFQFYGL
     PHKGYQPEKF VEETQKLSLR FCDGQRDPNL DARKGEFSDG GVFLPEYHRR IPADGFSRYA
     EGIWDQIVNN KDLDLPTQQE LLAQFRCDEI LREVMVAFDE TIVPFEDKQS QAARLGEPEI
     LGGLGAAMRS SRTKAVKAFE SEASRYHKGV YQRKRAELES KADTRLKTLF QGQLNAAHKS
     GISEFSEAVT AAVKSGQKKG TGYDFAEIVN EEAKKAVDKF EEVARATVVD GTSWSDYKQE
     LALYEKELAE VSARLRRDEM RRLASRVERW VQSRLGESVG LEFNALGSGR AGGGAPEKGD
     QPTEKKFWDR VWNVFVETVL DAERRFTDRA SSFDASLEEV DVGLWRLRRK SWGVLRAKID
     EEMIEGNLLL KLRENFEDKF RYDDAGVPRI WRPTDDIEGI YTRARESTLT LIPLLSKFRL
     DETSAPPPLD RWIGHTPSSA TSADEEDLAP IGGVDEEEGK SLEEEMTIVS DAKRQELTVR
     FKKAADGVYV EAKRSAIGGM TQVPLYFYGL LLALGWNEII AVLRNPAYFF LLFVCAVGAY
     ITYQLNLWGP IIKMTEAASN QAVTEGKKRL REFLESSDTG RQAIAMSTPG GSGRGGEEHE
     MSRLNQQGKS AAADEDVDDL
 
 
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