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SEY1_ASPTN
ID   SEY1_ASPTN              Reviewed;         854 AA.
AC   Q0D0W7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein sey1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   Name=sey1; ORFNames=ATEG_00417;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cooperates with the reticulon proteins and tubule-shaping DP1
CC       family proteins to generate and maintain the structure of the tubular
CC       endoplasmic reticulum network. Has GTPase activity, which is required
CC       for its function in ER organization. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER.
CC       Concentrated in punctae along the ER tubules. {ECO:0000255|HAMAP-
CC       Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; CH476594; EAU39063.1; -; Genomic_DNA.
DR   RefSeq; XP_001210503.1; XM_001210503.1.
DR   AlphaFoldDB; Q0D0W7; -.
DR   SMR; Q0D0W7; -.
DR   STRING; 341663.Q0D0W7; -.
DR   PRIDE; Q0D0W7; -.
DR   EnsemblFungi; EAU39063; EAU39063; ATEG_00417.
DR   GeneID; 4355171; -.
DR   VEuPathDB; FungiDB:ATEG_00417; -.
DR   eggNOG; KOG2203; Eukaryota.
DR   HOGENOM; CLU_011270_0_0_1; -.
DR   OMA; TNFDVMD; -.
DR   OrthoDB; 418635at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:EnsemblFungi.
DR   GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..854
FT                   /note="Protein sey1"
FT                   /id="PRO_0000384974"
FT   TOPO_DOM        1..741
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        742..762
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        763..765
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        766..786
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        787..854
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          50..299
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   REGION          668..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          824..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          474..500
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   COILED          695..715
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         60..67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   854 AA;  96095 MW;  D23481A8ECB6822E CRC64;
     MATNGHFASL GGDSSDKTAY EHGVQVIDEN KEFNPNLSKY LSIEDVTPAG FNYHLISVFG
     SQSTGKSTLL NHLFGTRFSV MSELERRQTT KGIWMSKNKN TEGSMASNIL VMDVEGTDGR
     ERGEDQDFER KSALFALATS EVLIVNIWEH QVGLYQGANM GLLKTVFEVN LQLFLKDKNT
     THRSLLFFVI RDFVGMTPLK NLQKTLMEDM SRLWDSISKP AGLEKSTVHD YFDFQFYGLP
     HKGYQPEQFV AETKKLSLRF REGHKDPSLD AQKGEFSDGG VFLPEYHRRI PADGFSRYAE
     GIWDQIVNNK DLDLPTQQEL LAQFRCDEIL REVMVAFDEA IVPFEDKQSQ AARLGEPEIL
     GGLGAAMRTA RAKAVKSFET EASRYHKGVY QRKRAELESK IDTRLKALFQ GQLNATHKSG
     INEFSDAVTT AVKSGQKKGT GYDFAEIVSE EVKKAMEKFE EVARTTTVEG TSWSDYSQEL
     ALYEKELAEV SARLRRDEMR RLATRVERWV QSRLGESVGL EFNALGSGRA GGGAPETGDK
     PTEKKFWDRV WNVFVETVLD AERRFTDRAS SFDASLEEVD VGLWRLRRKS WGVLRAKIDE
     EMIEGNLLLK LRENFEDKFR YDDAGVPRIW RPTDDIEGVY TRARESTLTL IPLLSKFKLS
     ETSAPPPLDR WVGHTPSSAT AADEEDLPPI GGVDEEEGKS LEEEMTILSD SKRQELIVRF
     KKAADGVYVE AKRSAIGGMT QVPLYFYGIL LALGWNEIIA VLRNPAYFFL LFVCAVAAYV
     TYQLNLWGPI LKMTEAASNQ ALAEGKKRLR EFLESSDTGR QAIAMSASGS EQHEMSRLNK
     QGKAAASDED GDDL
 
 
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