SEY1_ASPTN
ID SEY1_ASPTN Reviewed; 854 AA.
AC Q0D0W7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Protein sey1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN Name=sey1; ORFNames=ATEG_00417;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cooperates with the reticulon proteins and tubule-shaping DP1
CC family proteins to generate and maintain the structure of the tubular
CC endoplasmic reticulum network. Has GTPase activity, which is required
CC for its function in ER organization. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER.
CC Concentrated in punctae along the ER tubules. {ECO:0000255|HAMAP-
CC Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR EMBL; CH476594; EAU39063.1; -; Genomic_DNA.
DR RefSeq; XP_001210503.1; XM_001210503.1.
DR AlphaFoldDB; Q0D0W7; -.
DR SMR; Q0D0W7; -.
DR STRING; 341663.Q0D0W7; -.
DR PRIDE; Q0D0W7; -.
DR EnsemblFungi; EAU39063; EAU39063; ATEG_00417.
DR GeneID; 4355171; -.
DR VEuPathDB; FungiDB:ATEG_00417; -.
DR eggNOG; KOG2203; Eukaryota.
DR HOGENOM; CLU_011270_0_0_1; -.
DR OMA; TNFDVMD; -.
DR OrthoDB; 418635at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:EnsemblFungi.
DR GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR PANTHER; PTHR45923; PTHR45923; 1.
DR Pfam; PF05879; RHD3; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..854
FT /note="Protein sey1"
FT /id="PRO_0000384974"
FT TOPO_DOM 1..741
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 742..762
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 763..765
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 766..786
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 787..854
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT DOMAIN 50..299
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT REGION 668..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 474..500
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT COILED 695..715
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT BINDING 60..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ SEQUENCE 854 AA; 96095 MW; D23481A8ECB6822E CRC64;
MATNGHFASL GGDSSDKTAY EHGVQVIDEN KEFNPNLSKY LSIEDVTPAG FNYHLISVFG
SQSTGKSTLL NHLFGTRFSV MSELERRQTT KGIWMSKNKN TEGSMASNIL VMDVEGTDGR
ERGEDQDFER KSALFALATS EVLIVNIWEH QVGLYQGANM GLLKTVFEVN LQLFLKDKNT
THRSLLFFVI RDFVGMTPLK NLQKTLMEDM SRLWDSISKP AGLEKSTVHD YFDFQFYGLP
HKGYQPEQFV AETKKLSLRF REGHKDPSLD AQKGEFSDGG VFLPEYHRRI PADGFSRYAE
GIWDQIVNNK DLDLPTQQEL LAQFRCDEIL REVMVAFDEA IVPFEDKQSQ AARLGEPEIL
GGLGAAMRTA RAKAVKSFET EASRYHKGVY QRKRAELESK IDTRLKALFQ GQLNATHKSG
INEFSDAVTT AVKSGQKKGT GYDFAEIVSE EVKKAMEKFE EVARTTTVEG TSWSDYSQEL
ALYEKELAEV SARLRRDEMR RLATRVERWV QSRLGESVGL EFNALGSGRA GGGAPETGDK
PTEKKFWDRV WNVFVETVLD AERRFTDRAS SFDASLEEVD VGLWRLRRKS WGVLRAKIDE
EMIEGNLLLK LRENFEDKFR YDDAGVPRIW RPTDDIEGVY TRARESTLTL IPLLSKFKLS
ETSAPPPLDR WVGHTPSSAT AADEEDLPPI GGVDEEEGKS LEEEMTILSD SKRQELIVRF
KKAADGVYVE AKRSAIGGMT QVPLYFYGIL LALGWNEIIA VLRNPAYFFL LFVCAVAAYV
TYQLNLWGPI LKMTEAASNQ ALAEGKKRLR EFLESSDTGR QAIAMSASGS EQHEMSRLNK
QGKAAASDED GDDL