ID   SEY1_GIAIC              Reviewed;        1035 AA.
AC   A8BW14;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein SEY1 homolog;
DE            EC=3.6.5.-;
GN   ORFNames=GL50803_32509;
OS   Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=184922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB clone C6;
RX   PubMed=17901334; DOI=10.1126/science.1143837;
RA   Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA   Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA   Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA   Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E.J., Palm D.,
RA   Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA   Svard S.G., Sogin M.L.;
RT   "Genomic minimalism in the early diverging intestinal parasite Giardia
RT   lamblia.";
RL   Science 317:1921-1926(2007).
CC   -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC       development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; AACB02000054; EDO76831.1; -; Genomic_DNA.
DR   RefSeq; XP_001704505.1; XM_001704453.1.
DR   AlphaFoldDB; A8BW14; -.
DR   SMR; A8BW14; -.
DR   STRING; 5741.EDO76831; -.
DR   PRIDE; A8BW14; -.
DR   EnsemblProtists; EDO76831; EDO76831; GL50803_32509.
DR   GeneID; 5697368; -.
DR   KEGG; gla:GL50803_0032509; -.
DR   VEuPathDB; GiardiaDB:GL50803_32509; -.
DR   HOGENOM; CLU_293639_0_0_1; -.
DR   OMA; CEEFYLE; -.
DR   OrthoDB; 170211at2759; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding.
FT   CHAIN           1..1035
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000384948"
FT   DOMAIN          32..267
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   BINDING         42..49
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1035 AA;  116182 MW;  8EEA1CB5279F4FC1 CRC64;
     MSSKTEIPII TDEGDFSAEY ETFCQAMNGV ADGTFICVSV FGPQSSGKST LLNDLFGTSF
     KTMDLSAGRT QTTKGIMARA VDFQTKVAPR VLILDCEGSD SRERNQQEAQ NIERHIGCFA
     AAVSDLLIIN VWNHDIGRHS AANYNILSTI FDIYFRSLLK ARRKSGNHRP LILLIAIRDA
     EEDGAELTQR TFESDVHHIY EQSVPKQYHG SFRDYFCLRF WFIPHRRYMK SLYDEKITQL
     KTDIKEIFDS LLGAETATTL IPLTDSSIYY NNIWDIVRTD KDLDIPSQRE IVSNIRCEEF
     YLEAIEQFSS QVGKVFADVT AAIQVSLGQQ SSTFLEQSPD AVKDYPITKL HNACNSFKLT
     KVLMDLSQEC VALYRRKTRH YIPKVVTQWA TKLNDDVLAG LKKVAHSFAK GIRESTCQAL
     GAVTAPFRVQ ITQWLERHEY SDDYASNTNT VDILVPDLIS DLTFPQKRLT DLMGLLGAAT
     RVFHKCISVN WAHEYSGLCD TGILVNLPPN DVGPNSNVRI GDNAIETNAG SSVRLSVGYE
     ASEPMVDAHI DDSGAFFSDI RQTGVYSPHL YAFLESLSLS TYGKALSLQK LPAAPPDVAN
     AYDAVCLLHT IILLWYCETM MPLSLIYDIT PEIDHVIPES NALFCETMGS ILAAVAEAVS
     SQTRTITASM TQATARLMDD KLYVTLGSLR GVIYESARKT LERSFFSLLS SAFVAPDHQG
     LLYLQTRLSS PSIYFDLHFD SSSRSSPTDS ILPDTQNPVY KQYTDIYLFS TLPALLSPLP
     RAYNTVGTRL SSGSSSIQSL LPRYRAVPIV AALDMSAFYI PQAALSSFMD RVDAEIIELI
     NKSLGEFFSK SFPLVLQNKI HTKLVYDDQG AQRSYISENS ILTEFLSEKK GLISMAQLFE
     GGTLITENLH SVTIKPTSQE KIDAMLRCAE AEWDKTYQEA LEIYRTNKHK DKYKWVWLGL
     CVFLMLTRKW VYAVLLSKYC LCITILLLSV GLFVYQRTTP DERNASFSIV ATSIRERDVG
     QFWDATKRLA QKVIH