ID   SEY1_PLABA              Reviewed;         913 AA.
AC   A0A509AN59;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   03-AUG-2022, entry version 16.
DE   RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE            Short=PbSEY1 {ECO:0000303|PubMed:27484902};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   Name=SEY1 {ECO:0000303|PubMed:27484902};
GN   ORFNames=PBANKA_1026600 {ECO:0000312|EMBL:VUC56263.1};
OS   Plasmodium berghei (strain Anka).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5823 {ECO:0000312|Proteomes:UP000074855};
RN   [1] {ECO:0000312|Proteomes:UP000074855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANKA {ECO:0000312|Proteomes:UP000074855};
RX   PubMed=25359557; DOI=10.1186/s12915-014-0086-0;
RA   Otto T.D., Bohme U., Jackson A.P., Hunt M., Franke-Fayard B.,
RA   Hoeijmakers W.A., Religa A.A., Robertson L., Sanders M., Ogun S.A.,
RA   Cunningham D., Erhart A., Billker O., Khan S.M., Stunnenberg H.G.,
RA   Langhorne J., Holder A.A., Waters A.P., Newbold C.I., Pain A., Berriman M.,
RA   Janse C.J.;
RT   "A comprehensive evaluation of rodent malaria parasite genomes and gene
RT   expression.";
RL   BMC Biol. 12:86-86(2014).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=27484902; DOI=10.1007/s13238-016-0290-5;
RA   Sun S., Lv L., Yao Z., Bhanot P., Hu J., Wang Q.;
RT   "Identification of endoplasmic reticulum-shaping proteins in Plasmodium
RT   parasites.";
RL   Protein Cell 7:615-620(2016).
CC   -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC       maintaining the structure of the tubular endoplasmic reticulum network.
CC       {ECO:0000269|PubMed:27484902}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
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DR   EMBL; LK023125; VUC56263.1; -; Genomic_DNA.
DR   STRING; 5823.A0A509AN59; -.
DR   VEuPathDB; PlasmoDB:PBANKA_1026600; -.
DR   OMA; WREISMA; -.
DR   Proteomes; UP000074855; Chromosome 10.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1990809; P:endoplasmic reticulum tubular network membrane organization; IDA:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..913
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000454704"
FT   TOPO_DOM        1..825
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        826..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        847..849
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        850..870
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        871..913
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          33..288
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   BINDING         43..50
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   913 AA;  106843 MW;  462824B3CC609E3E CRC64;
     MTDVNKTQII DYDGHIIDNL KEWMNNNKLS KLGFNYNVIA ILGSQSSGKS TLLNNLFKTS
     FDVMNTKLGH SQTTQGLWLS YDKFEDELTD ASNEETDVEP QNKSNNKHVI NPTLILDVEG
     NDSKERGENR LTFEHRSALF SLALADCVIV NLWYHSLGNF TASNYGLLKT VMEVHLELFH
     QNVNCPKTIL LFTVRDWFEE FAPLDIIREK IVDEYVNKIW CELKKSENSK NANIDDYFII
     EVVGLSHGII KKDEFLKDIK RLRHKWIYEL RPINYSRNIP ADGFAQYCNN IWNTIIKQSQ
     LDIPSQQEML ATFRCQEIKN NVLNHISNTI KEKMVDSKNK YIENFKTWAE KDIIEKSLNE
     YLTDAARYQK IICLKTLEEL LENLFIQLQI IVDNNLNFTQ RILSSKFSKE LNSMYSICTT
     DKSYFLFIND QNVDVTEQDE NLSNVENIGE NSKKGNQIKC INLWSNFLYN ADMLEYTTIA
     NFFDQYKKCS VEIIEPSISN NEDKDSQEKR NHDFNYKNSL TILATSIYKD TNRIRSVQCN
     ILIERIRSTI KEELKNVDNM LITVKCSKDC WDYILKIVNK LEDYIYTNLS KCFINLKTGI
     NTTYLNNGDN IYARLNTNCD YGLGYFQNEQ ITDFSDDAGK NDDEMDTEID QNKNDMESLF
     NSKKFEIITK QNKKEKYVST INNDLNKEMN NKKLISELKK FYTEIIIDAL KIKLDEISNN
     IANIIINRFE SVFNYDEIDQ PRQWRNISAI ELKNIFRVSK DYAFLIIEIL QKNIKIDKID
     NYLSTNFINT DIIEKGKIKA KKRIQEICRD AQYIQETGGH MSLKNVPFAF WVILLILGWN
     EILMFTRLFF RLNIILPMLI GFIIIVISCL YTGNAQILSY INKIIFIVIK NLYNFYKHLQ
     TIGHQTTKPE KVE