SEY1_PLAF7
ID SEY1_PLAF7 Reviewed; 937 AA.
AC Q8ILT5; A0A144A1B3;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN Name=SEY1 {ECO:0000250|UniProtKB:A0A509AN59};
GN ORFNames=PF14_0159, PF3D7_1416100;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC maintaining the structure of the tubular endoplasmic reticulum network.
CC {ECO:0000250|UniProtKB:A0A509AN59}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR EMBL; LN999946; CZT99872.1; -; Genomic_DNA.
DR RefSeq; XP_001348332.2; XM_001348296.2.
DR AlphaFoldDB; Q8ILT5; -.
DR SMR; Q8ILT5; -.
DR STRING; 5833.PF14_0159; -.
DR PRIDE; Q8ILT5; -.
DR EnsemblProtists; CZT99872; CZT99872; PF3D7_1416100.
DR GeneID; 811740; -.
DR KEGG; pfa:PF3D7_1416100; -.
DR VEuPathDB; PlasmoDB:PF3D7_1416100; -.
DR HOGENOM; CLU_312978_0_0_1; -.
DR InParanoid; Q8ILT5; -.
DR OMA; WREISMA; -.
DR PhylomeDB; Q8ILT5; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR PANTHER; PTHR45923; PTHR45923; 1.
DR Pfam; PF05879; RHD3; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..937
FT /note="Protein SEY1 homolog"
FT /id="PRO_0000384955"
FT TOPO_DOM 1..848
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 849..869
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 870..872
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 873..893
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 894..937
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT DOMAIN 34..280
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT COILED 319..339
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT COILED 725..750
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT BINDING 44..51
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ SEQUENCE 937 AA; 110609 MW; 0105532D574D6D20 CRC64;
MEKGVEKTQI IDYDGNVIED LKEWMIDNKL NDLGFSYNVI AVLGSQSSGK STLLNNLFKT
SFDVMNTKQG HSQTTKGLWL SYDKFDDETN NSSSFFKLKK KNKPTLILDV EGTDSKERGD
NRLTFEHRSA LFCLALADCV IVNLWYHSLG NFTASNYGLL KTVMEVNLEL FQQEKNSPKT
ILLFTVRDWF EEFAPIEVVR NKILDEYINK IWKEMKKPKE AEKLNINNFF IIEVVGLSHG
IIKKEDFLKD VNNLRDKWIN NLRPSKYSRN IPSDGFAQYC NNIWNTIVKQ SQLDIPSQKE
MLSTFRCQEI KNNVINNINK EIKEKSIESH NKVIENFKEW AEKNIIQKCL DDYFKDASRY
KENICLRTSQ ELLDYLFTQL QAIVDNNLQY IQRTLCTKFF NELSNMYKIC TIEKNTFSFS
RDSNLKTVKD NNKNTSHEDI KRDLLNNNQD KCVHLWSNFL YNADKLEYFT FCNFYENYEK
SNIEIKTNMK NDDNLKNDDN LKNDAHNNIT THQFNYKPTL SVLSTSIYKD SNRIRNIQCG
ILLNKTRQTI KNSFKNMDTY LLTTKNTEEY WNNTVQLVLK LQDNINTHLT KCFINLKGTN
HNNLNIYNDD MMYNNDDMVF NNNDDDDNNN NNNNNNYYYY NKNDDANLSK DENYNNKFSF
SLTNEKGIFQ NINNNNEGSD EICYTNALKK IDLIKNKQVY KSTINEDINN KLQNKKYIHE
LKNYYLDEIM DVLKNKLDEI SENLATIIIQ RFESVFNYDE YEQPRQWRDI SMAELKKIFL
KSKNYAFLII DILQKNIKVE LIDDYLPNNF IKDEIIEKGK IKAKRRIQEI CRDAQYIQET
GSKMSLKNVP VVFWIILLLF GWNEILFFIR MFFKLNVILP LFFAAAFIVS TFVYNGNTQA
LSYINKIIFY MAKNSYNFFK HIQAISNPPP KNVQKQE
