ID   SEY1_PLAKH              Reviewed;         883 AA.
AC   B3LAJ9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   Name=SEY1 {ECO:0000250|UniProtKB:A0A509AN59}; ORFNames=PKH_133110;
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H;
RX   PubMed=18843368; DOI=10.1038/nature07306;
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R.D., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M.A., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clark T.G., Galinski M.R., Hall N., Harper D., Harris D.,
RA   Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S., Marti M.,
RA   Moule S., Meyer I.M., Ormond D., Peters N., Sanders M., Sanders S.,
RA   Sargeant T.J., Simmonds M., Smith F., Squares R., Thurston S., Tivey A.R.,
RA   Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A., Cowman A.F.,
RA   Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W., Newbold C.I.,
RA   Barrell B.G., Berriman M.;
RT   "The genome of the simian and human malaria parasite Plasmodium knowlesi.";
RL   Nature 455:799-803(2008).
CC   -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC       maintaining the structure of the tubular endoplasmic reticulum network.
CC       {ECO:0000250|UniProtKB:A0A509AN59}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; AM910995; CAQ42803.1; -; Genomic_DNA.
DR   RefSeq; XP_002260831.1; XM_002260795.1.
DR   AlphaFoldDB; B3LAJ9; -.
DR   SMR; B3LAJ9; -.
DR   STRING; 5851.B3LAJ9; -.
DR   EnsemblProtists; CAQ42803; CAQ42803; PKH_133110.
DR   GeneID; 7322988; -.
DR   KEGG; pkn:PKNH_1342000; -.
DR   VEuPathDB; PlasmoDB:PKNH_1342000; -.
DR   HOGENOM; CLU_312978_0_0_1; -.
DR   InParanoid; B3LAJ9; -.
DR   OMA; WREISMA; -.
DR   PhylomeDB; B3LAJ9; -.
DR   Proteomes; UP000031513; Chromosome 13.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..883
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000384956"
FT   TOPO_DOM        1..795
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        796..816
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        817..819
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        820..840
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        841..883
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          33..279
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   COILED          673..693
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         43..50
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   883 AA;  102015 MW;  78A1320621567C31 CRC64;
     MQMDRKTQII DYDGNMIADL KEWMIRNKLA NLGFNYNVVA ILGSQSSGKS TLLNNLFKTS
     FDVMNTKLGH SQTTQGLWLS FDTFEESPVS PLEKGNSTTP INPTLILDVE GNDSKERGDN
     RLTFEHRSAL FSLALADCLI VNLWYHSLGN FTASNYGLLK TVMEVNLELF QQDKNCPKTI
     LLFTVRDWFE EFASIDIVKN KIVEEYLNKI WAEMKKPPSA KKANINNYFI VEVVGLSHAI
     IKKTEFLNDV ENLRKKWINE LRPLQYSRNI PSDGFAHYCN NIWNTIVKQS QLDIPSQKEM
     LATFRCQEIK NNVISNTSKM IKEKLTASSS QPTSASIDEF KSWAEKDIVE KSLDEYFVDA
     SRYTESICLK TSEELLESLF IQLQTIVDNN LNFTQRVLSA KFANELNTMY SVCTSDKNVF
     LFSKESNLQV HKDGNGSNSS KEDKKDENTS QDKCIRLWSS FLSNADKLEY ITFCNFFESY
     QKCNIEIRKK NKIHEFNYKP SLNILLTSIC KDMNRIRNTQ FTVLLERTRA TIKSRFKNMD
     NLLITTKNPE EYWNHTLKIV KALQESINNN LTKCFINLKG GGPGSSVAGI SNELFDHDED
     NTFHVDSPSE GHRSISDNRT AHENKHYVDE NLLNYKKIDI IKNKGKYISS VSEEIDKQIK
     NKKAISELNN YYLDEIMDVL KSKLDEISDN LSSIIIQRFE SVFNYDDAEQ PRHWREISMA
     ELKKIFRESK NYAFLIIDIL QKNIKVELID DYLPNNFIKD EVIEKGKNKA KRKIQEICRD
     AQYIQETGGK MSLKNVPLFF WVILLILGWN ELLFFIRFFF RLNIILPLFL AAAVILSTLF
     FNGNMEVLST INKVVFFLAK SSFGFYRQLQ TMGEKVAQVP TAD