ID   SEY1_PLAVS              Reviewed;         889 AA.
AC   A5K168;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   Name=SEY1 {ECO:0000250|UniProtKB:A0A509AN59}; ORFNames=PVX_085645;
OS   Plasmodium vivax (strain Salvador I).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=126793;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Salvador I;
RX   PubMed=18843361; DOI=10.1038/nature07327;
RA   Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA   Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q.,
RA   Coulson R.M.R., Crabb B.S., del Portillo H.A., Essien K., Feldblyum T.V.,
RA   Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA   Kooij T.W.A., Korsinczky M., Meyer E.V.-S., Nene V., Paulsen I., White O.,
RA   Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA   Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA   Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT   "Comparative genomics of the neglected human malaria parasite Plasmodium
RT   vivax.";
RL   Nature 455:757-763(2008).
CC   -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC       maintaining the structure of the tubular endoplasmic reticulum network.
CC       {ECO:0000250|UniProtKB:A0A509AN59}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; AAKM01000002; EDL47065.1; -; Genomic_DNA.
DR   RefSeq; XP_001616792.1; XM_001616742.1.
DR   AlphaFoldDB; A5K168; -.
DR   SMR; A5K168; -.
DR   STRING; 126793.A5K168; -.
DR   EnsemblProtists; EDL47065; EDL47065; PVX_085645.
DR   GeneID; 5476100; -.
DR   KEGG; pvx:PVX_085645; -.
DR   VEuPathDB; PlasmoDB:PVX_085645; -.
DR   InParanoid; A5K168; -.
DR   OMA; WREISMA; -.
DR   PhylomeDB; A5K168; -.
DR   Proteomes; UP000008333; Chromosome 13.
DR   Proteomes; UP000008333; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..889
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000384957"
FT   TOPO_DOM        1..801
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        802..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        823..825
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        826..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        847..889
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          31..277
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   REGION          429..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          679..699
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         41..48
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   889 AA;  101652 MW;  B8A740DA3CAC4C83 CRC64;
     MDTKTQIIDY DGNIMEDLKE WMIRNKLANL GFNYNVIAIL GSQSSGKSTL LNNLFKTSFD
     VMNTKLGHSQ TTQGLWLSFD TFEDSSAGPS EQGSTTRKVN PTLILDVEGN DSKERGDNRL
     TFEHRSALFS LALADCVIVN LWYHSLGNFT ASNYGLLKTV MEVNLELFQQ DENCPKTILL
     FTVRDWFEEF ASIDIVKNKI VEEYLNKIWT EMKKPPEAEK VNISNYFIVE VVGLSHGIIK
     KEEFLKDVEN LRQKWINQLR PLQYSRNIPS DGFAHYCNNI WNTIVKQSQL DIPSQKEMLA
     TFRCQEIKNN VISNASKVIK EKLAASSSQH SSTSIDEFKP WAEKEVVEKS LDEYFVDASR
     YTESICLKTS EELLDSLFIQ LQTIVDNNLN FTQRVLAAKF ANELNTMYSV CASDKNVFLF
     SKESNLQVRK DGKGGSSPSA GDKKDTKDTR SSQDKCIRLW SSFLLNADKL EYNTLCKFFE
     DYQKCNIEVK KRNKTHEFNY KPSLSILSTA ICKDLNRIRN AQLTVLLDRT RATIKSRFKN
     MESLLITTKN PEEYWNHTLK IVKALQESIN SNLTKCFINL KGGGAGPGSI TTAGIIPNGG
     LYNDEDNTFH EDNLVEAHNS LSDNQTGHEN DHYVEENLLN FHKIDVIKNK GKYISTVGEE
     IDKQVKNKNA IAELNSYYLD EIMDVLKSKL DEISDNLSSI IIQRFESVFN YDDAEQPRQW
     REISMAELKK IFRESKNYAF LIIDILQKNV QVEIIDDYLP NNFIKDEIVE KGKNKAKRKI
     QEMCRDAQYI QETGAKMSLK NVPLFFWVIL LILGWNELLF FTRFFFRLNI ILPLFLAAAV
     ILSTLVFNGN MEVLSIINKA VFFLAKNSFG VYRQLQAMGG KAAQGAAAD