ID   SEY1_THEAN              Reviewed;         918 AA.
AC   Q4U9I8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   ORFNames=TA08650;
OS   Theileria annulata.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ankara;
RX   PubMed=15994557; DOI=10.1126/science.1110418;
RA   Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA   Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA   Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA   Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA   McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA   Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA   Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA   Shiels B., Tait A., Barrell B.G., Hall N.;
RT   "Genome of the host-cell transforming parasite Theileria annulata compared
RT   with T. parva.";
RL   Science 309:131-133(2005).
CC   -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC       development. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; CR940353; CAI76515.1; -; Genomic_DNA.
DR   RefSeq; XP_953140.1; XM_948047.1.
DR   AlphaFoldDB; Q4U9I8; -.
DR   SMR; Q4U9I8; -.
DR   STRING; 5874.XP_953140.1; -.
DR   PRIDE; Q4U9I8; -.
DR   GeneID; 3863163; -.
DR   KEGG; tan:TA08650; -.
DR   VEuPathDB; PiroplasmaDB:TA08650; -.
DR   eggNOG; KOG2203; Eukaryota.
DR   eggNOG; KOG3362; Eukaryota.
DR   InParanoid; Q4U9I8; -.
DR   OMA; TNFDVMD; -.
DR   OrthoDB; 418635at2759; -.
DR   Proteomes; UP000001950; Chromosome 4.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   InterPro; IPR007529; Znf_HIT.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   Pfam; PF04438; zf-HIT; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..918
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000384958"
FT   TOPO_DOM        1..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        702..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        723..725
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        726..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        747..918
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          46..280
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   COILED          554..626
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         56..63
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   918 AA;  105667 MW;  A13E99912AA2B5CC CRC64;
     MESSNHLPNK DSDTVSVTPV EFSNYQCEIN PGFNDFLKKS GFEDFGFKFN VVTILGSQSS
     GKSHLLNSLF NASFQTMDAS KGHSQTTKGI WGSLVLSKDT SMNATVVFDS EGTDSRERGE
     GRLTFEHRSS LFCLALSDVV IVNIWYNSMG NLTGSNYGLL KTVVEANLEL VDTNNEENYK
     TVLFFCVRDW SPSLSPLNVV KDYVLNNYMS SIWNEISKPA RFENLGVESL FEIRVFGLSN
     AVTQSESFEM DVKEVKKTWN SLKPREYSRR VPSDGFFVYS KNVWKTIIEQ NHLDIPTQKE
     MLSSYRCSEI KTMILESLTN ALPELKEKDF SEYLMGLLKK VENQYFSQAS RYDPVVSKKV
     GKELLEQVCR KFQPFFESAL GDYVKKLAVE SSSLLDKEFS VNSSGKELKV SNARPYTVWP
     NFSKKCEELQ KKQTEKLSHH LSSFKVTFKS TVSFEFEFEY QPLKDHLNLL VSSEFEVLRS
     RHLELLKQQL DSMCNSCFAL VKNNMMDRSL NEDQFWDYFD ELFDETHKNC VDQLTTSYVG
     LVKGATRTEF EQLSLVLLLK ATQSNFEELQ NNLEQLLLER FDKFFNYQEF KGELIPTEWH
     KQSAQELNNR YKESKEDALT LLQVLKTTKT KKLPSFDANY VKKNQYFYST LEGPVSDKYS
     SPLTEQFTIE LTNSCSKKFM EMYKNAQVVQ NAGTSVSSWR NIPPVFWLVL LVLGWNELRA
     AFRVLLKFYI LIPLLIVSYF TFSYSANKLL GPKANEYVKP VRDKALSLLT ALFAWFVRTL
     HMIASKSSSF KQQTKNLKMA KKGNKNRDSD DEYVGKTVTK SSHSIYKHRE PMDINLIVDH
     DEVEAEKNNL PCWRAAYASG PARPQRHLCV ICGFFANYKC RNCATRRIEA INSYYCSLRC
     LEVHNETNCG KAVHLAQW