ID   SEY1_THEPA              Reviewed;         796 AA.
AC   Q4N280;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein SEY1 homolog {ECO:0000255|HAMAP-Rule:MF_03109};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN   OrderedLocusNames=TP04_0477;
OS   Theileria parva (East coast fever infection agent).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga;
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA   Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA   Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA   Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA   Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA   Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA   Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA   Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC       development. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03109}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAN31829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAGK01000004; EAN31829.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_764112.1; XM_759019.1.
DR   AlphaFoldDB; Q4N280; -.
DR   SMR; Q4N280; -.
DR   STRING; 5875.XP_764112.1; -.
DR   EnsemblProtists; EAN31829; EAN31829; TP04_0477.
DR   GeneID; 3500909; -.
DR   KEGG; tpv:TP04_0477; -.
DR   VEuPathDB; PiroplasmaDB:TpMuguga_04g00477; -.
DR   eggNOG; KOG2203; Eukaryota.
DR   InParanoid; Q4N280; -.
DR   Proteomes; UP000001949; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03109; Sey1; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PTHR45923; 1.
DR   Pfam; PF05879; RHD3; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..796
FT                   /note="Protein SEY1 homolog"
FT                   /id="PRO_0000384959"
FT   TOPO_DOM        1..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        702..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        723..725
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TRANSMEM        726..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   TOPO_DOM        747..796
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   DOMAIN          46..280
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   COILED          554..626
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT   BINDING         56..63
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ   SEQUENCE   796 AA;  91335 MW;  D21157CF80270B3B CRC64;
     MESSNDFSNK DSDTVSLSPV EFSNYQCEIN PGFHEFLKKS GFEDVGFRFN VVTILGSQSS
     GKSHLLNSLF NASFQTMDAS RGHSQTTKGI WGSLVLPKDT SVSATVVFDS EGTDSRERGE
     GRLTFEHRSS LFCLALSDVV IVNLWYNSMG NLTGSNYGLL KTVVEANLEL VDTNNEENYK
     TVLFFCVRDW SPSLSPLNVV KDYVLNNYMR SIWNEISKPA RFENMGVESL FEIRVFGLSN
     AVTQPELFEK DVKEVKKTWE SLKPKEYSRR VPSDGFFVYS KNVWKTIIEQ NHLDIPTQKE
     MLSSYRCSEI KTAILESATT SVPELTETDF SEYLMSLLNK VESEYFSQAS RYDPKVSEKV
     GKELLSQLCG KFQPCFESAL AGYVKKLAVE SSSLLDKEFT VNSSGKELKV ANARPYTVWP
     SFSKKCEELQ SKQSEKLSEH LSRFKVSFNK TVSFEYEFDA QPLKDHLNLL VSTEFEVLRS
     RHLGLLKQQL DSMCNSTFVM VKNNLLDRSL TEDEFWDYFD ELFDETHKNC MDQLTTSYQG
     LVNRASKAEF AQLSLVLLLK AARHNFDELQ NNLEQLLLER FDKFFNYQEF KGELVPTEWH
     KQSAQELNNR YKESKEDALT LLKVLKKTKT KKMPSFDLND VKKNQYFYST LGEPVSDKYS
     TPVTEQFALE VTNSCSKKFL EMYKNAQVVQ NAGTSISSWR NIPPIFWLVL LVLGWNELRS
     VFKVLLRFYV VIPLLIVFYF TFSYSATKLL GPKADQYVKP VRDKVLSLFT ALLAWFVRTL
     HMIASKSSSF KQRPAT