SEY1_UNCRE
ID SEY1_UNCRE Reviewed; 862 AA.
AC C4JQN4;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Protein SEY1 {ECO:0000255|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_03109};
GN Name=SEY1 {ECO:0000255|HAMAP-Rule:MF_03109}; ORFNames=UREG_03379;
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Cooperates with the reticulon proteins and tubule-shaping DP1
CC family proteins to generate and maintain the structure of the tubular
CC endoplasmic reticulum network. Has GTPase activity, which is required
CC for its function in ER organization. {ECO:0000255|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER.
CC Concentrated in punctae along the ER tubules. {ECO:0000255|HAMAP-
CC Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU01052}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476616; EEP78533.1; -; Genomic_DNA.
DR RefSeq; XP_002543862.1; XM_002543816.1.
DR AlphaFoldDB; C4JQN4; -.
DR SMR; C4JQN4; -.
DR STRING; 33188.XP_002543862.1; -.
DR EnsemblFungi; EEP78533; EEP78533; UREG_03379.
DR GeneID; 8440218; -.
DR KEGG; ure:UREG_03379; -.
DR VEuPathDB; FungiDB:UREG_03379; -.
DR eggNOG; KOG2203; Eukaryota.
DR HOGENOM; CLU_011270_0_0_1; -.
DR InParanoid; C4JQN4; -.
DR OrthoDB; 418635at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR PANTHER; PTHR45923; PTHR45923; 1.
DR Pfam; PF05879; RHD3; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..862
FT /note="Protein SEY1"
FT /id="PRO_0000385003"
FT TOPO_DOM 1..747
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 748..768
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 769..771
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TRANSMEM 772..792
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT TOPO_DOM 793..862
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT DOMAIN 49..306
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT REGION 819..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..507
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
FT BINDING 59..66
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03109"
SQ SEQUENCE 862 AA; 97564 MW; 52F62EE6BC507D56 CRC64;
MVSNGHFASA GDDSFATSYE HGVQVVDEDK EFNRNLSKYL AYENVTPAGF NYHLISVFGS
QSTGKSTLLN HLFGTHFSVM AETERRQTTK GIWMSKNKRQ EPQRENSLPH VQNPNMADNI
LVMDVEGTDG RERGEDQDFE RKSALFALAT SEVLIVNIWE HQVGLYQGAN MGLLKTVFEV
NLQLFLKDKR SSPRSLLFFV IRDFLGTTPL QNLQNTLMQD LQRIWTSLSK PSGLEDSRIE
DYFDFEFAAL PHKNFQPDKF VAEVKKLTLR FREGHREPSK HNKTEGGIFL PEYHRRIPAD
GFAVYAEGIW DQIVNNKDLD LPTQQELLAQ FRCDEISREV LVAFDEAIVP FETKQAEAAQ
SGNPEVLGGL GPAMKNARAK TVKGFETEAS RYHKRVYQMK KAELEEKVDT RLKALFAGQL
AAAHKSGISQ FSDAVTAAVK AGQKKGASYD FADIVSKERK LALETFEKDA KATVVDGTSW
SNYTQELALY QKDLEKISAQ LRKDEMRRLA TRVERWVRSR LGESVGLEFN ALGSGRGGSG
APETGDKPSE DTIWDRIWSI FVDTVLDAER RFTERASSFD ASLEEVDVGL WRLRRKAWGV
LRSKIDEEMM EGNLLLKLRE NFEDKFRYDA AGVPRIWRPT DDIEGLYTKA RESTLTLIPL
LSRFRLRETD TPPQLDRWVG YTPSSATPAD EEDLAPIGGV DDDGMSLEEE MTMLSESKRQ
DLTVRFKKAA DGVYVEAKRS AIGGMTQIPV YFYILLLALG WNEIVAVLRN PLYFFMLFLC
AVGAFVTYQL NLWGPMIKMA EAASHQALEE GKKRLRDFLE PSEAGPHAAR YKNSTEEYEM
SNVKAPQRTN SGDDDDEDEG SW
