SF3A2_DICDI
ID SF3A2_DICDI Reviewed; 215 AA.
AC Q54B65;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Splicing factor 3A subunit 2;
GN Name=sf3a2; ORFNames=DDB_G0293876;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing as a component of the splicing
CC factor SF3A complex that contributes to the assembly of the 17S U2
CC snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex
CC and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA
CC splicing as a component of pre-catalytic spliceosome 'B' complexes,
CC including the Bact complex. {ECO:0000250|UniProtKB:Q15428}.
CC -!- SUBUNIT: Component of splicing factor SF3A which associates with the
CC splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small
CC nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the
CC spliceosome 'E' complex, a precursor of the spliceosome 'A' complex.
CC Identified in the spliceosome 'A' and 'B' complexes. Identified in the
CC spliceosome 'C' complex. {ECO:0000250|UniProtKB:Q15428}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15428}.
CC -!- SIMILARITY: Belongs to the SF3A2 family. {ECO:0000305}.
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DR EMBL; AAFI02000223; EAL60509.1; -; Genomic_DNA.
DR RefSeq; XP_628923.1; XM_628921.1.
DR AlphaFoldDB; Q54B65; -.
DR SMR; Q54B65; -.
DR STRING; 44689.DDB0233181; -.
DR PaxDb; Q54B65; -.
DR PRIDE; Q54B65; -.
DR EnsemblProtists; EAL60509; EAL60509; DDB_G0293876.
DR GeneID; 8629465; -.
DR KEGG; ddi:DDB_G0293876; -.
DR dictyBase; DDB_G0293876; sf3a2.
DR eggNOG; KOG0227; Eukaryota.
DR HOGENOM; CLU_050757_0_0_1; -.
DR InParanoid; Q54B65; -.
DR OMA; EPYEIIG; -.
DR PhylomeDB; Q54B65; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q54B65; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; ISS:dictyBase.
DR GO; GO:0005686; C:U2 snRNP; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR GO; GO:1903241; P:U2-type prespliceosome assembly; ISS:UniProtKB.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR031781; SF3A2_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR Pfam; PF16835; SF3A2; 1.
DR SMART; SM00451; ZnF_U1; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
PE 3: Inferred from homology;
KW Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome; Zinc; Zinc-finger.
FT CHAIN 1..215
FT /note="Splicing factor 3A subunit 2"
FT /id="PRO_0000328490"
FT ZN_FING 50..80
FT /note="Matrin-type"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 25071 MW; 1EB76C7EC93E895B CRC64;
MSEYGKAGSG GLQSSQYDNI DRRERQKQLV LEHVDVSKDP YIISNHIGSF ECRLCLTVHN
NVGNYLAHTQ GKKHQTHLAR RAAKEQRENP SVSKNNYIQT TRVIHKKTIK IGRPGYKIIK
QRDSKTGQLS LLFQIDYPEI ESGLQPRHRI MSAFEQRVEQ PNKDYQYLLF AAEPYETIAF
KIPNKEIDRT TGPDGKFFTH WDRNKTFTLQ LYFKE
