ID   SF3B3_DICDI             Reviewed;        1256 AA.
AC   Q54SA7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable splicing factor 3B subunit 3;
GN   Name=sf3b3; ORFNames=DDB_G0282569;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the splicing
CC       factor SF3B complex, a constituent of the spliceosome. SF3B complex is
CC       required for 'A' complex assembly formed by the stable binding of U2
CC       snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence
CC       independent binding of SF3A/SF3B complex upstream of the branch site is
CC       essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved
CC       in the assembly of the 'E' complex. Belongs also to the minor U12-
CC       dependent spliceosome, which is involved in the splicing of rare class
CC       of nuclear pre-mRNA intron. {ECO:0000250|UniProtKB:Q15393}.
CC   -!- SUBUNIT: Identified in the spliceosome A complex; remains associated
CC       with the spliceosome throughout the splicing process. Component of the
CC       spliceosome B complex. Identified in the spliceosome C complex.
CC       Identified in the spliceosome E complex. Component of the U11/U12
CC       snRNPs that are part of the U12-type spliceosome. Component of splicing
CC       factor SF3B complex which is composed of at least eight subunits. SF3B
CC       associates with the splicing factor SF3A and a 12S RNA unit to form the
CC       U2 small nuclear ribonucleoproteins complex (U2 snRNP).
CC       {ECO:0000250|UniProtKB:Q15393}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15393}.
CC   -!- SIMILARITY: Belongs to the RSE1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66144.1; -; Genomic_DNA.
DR   RefSeq; XP_640132.1; XM_635040.1.
DR   AlphaFoldDB; Q54SA7; -.
DR   SMR; Q54SA7; -.
DR   STRING; 44689.DDB0233171; -.
DR   PaxDb; Q54SA7; -.
DR   EnsemblProtists; EAL66144; EAL66144; DDB_G0282569.
DR   GeneID; 8623669; -.
DR   KEGG; ddi:DDB_G0282569; -.
DR   dictyBase; DDB_G0282569; sf3b3.
DR   eggNOG; KOG1898; Eukaryota.
DR   HOGENOM; CLU_003246_0_0_1; -.
DR   InParanoid; Q54SA7; -.
DR   OMA; FFLVQTE; -.
DR   PhylomeDB; Q54SA7; -.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR   PRO; PR:Q54SA7; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:dictyBase.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..1256
FT                   /note="Probable splicing factor 3B subunit 3"
FT                   /id="PRO_0000327995"
FT   REGION          671..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1256 AA;  139855 MW;  631B387FE0B75FF9 CRC64;
     MYLYNLTLQR PTSVYQSISG NFSGTKQVEI VLNHGRSLEL IRYDENGKMQ SVLYTEVFGI
     VRSIIPFRLT SGTKDYIIVG SDSGRVVILE YNSQKNQFDK IHQETFGRSG CRRIVPGQYL
     AVDPKGRAFM IGAIEKQKLV YILNRDSSAN LTISSPLEAH KSNTIVFSMC GVDVGFDNPI
     FATISVDYTE EDSSSGGGGG GSIEEMMDED IGKKKKLLTY YELDLGLNNV VRKWSDQVDD
     SANIVMTVPG GTEGPGGVLV ASEDYIVYRN QDHAEVRSRI PRRYGSDPNK GVLIISHSSH
     KQKGMFFFLV QSEHGDLYKI TLDYQGDQVS EVNVNYFDTI VLANCLTVLK NGFLFAASEF
     GDHTLYFFKS IGDEEEEGQA KRLEDKDGHL WFTPRNSCGT KMEELKNLEP TSHLSSLSPI
     IDFKVLDLVR EENPQLYSLC GTGLNSSLKV LRHGLSVTTI TTANLPGVPS GIWTVPKSTS
     PNAIDQTDKY IVVSFVGTTS VLSVGDTIQE NHESGILETT TTLLVKSMGD DAIIQVFPTG
     FRHIKSDLRI NEWRAPGRKT IVRASANQSQ LAIALSGGEI IYFELDQASN LIEIIKKDLR
     RDIACIEISP IPKGRNMARF IAVSDWEGPI RVLSLDRDNC LGQVSMLDTD KVYIESLSII
     EMQLNEMGIE TKKSQSQTGQ TTTTTTSTSS ASSSVTSGGS LFLFVGLKNG VVKRATLDSV
     TGELSDIRTR LLGRKPVKLF KVKVRGSNAM LALSSRVWLN YINQGKLDIV PLSIEPLENA
     SNLSSEQSAE SIVATSENKI IIFSIDKLGD LFNQETIKLN ATPKRFIIHP QTSYIIILET
     ETNYNTDNID IDKINEQSEK LLLEKQKELQ QEMDIDDDDQ NNNNEIEPFK KLFKPKAGKG
     KWKSYIKIMD PITHESLESL MLEDGEAGFS VCTCSFGESG EIFLVVGCVT DMVLNPKSHK
     SAHLNLYRFI DGGKKLELLY KTEVEEPVYA MAQFQGKLVC GVGKSIRIYD MGKKKLLRKC
     ETKNLPNTIV NIHSLGDRLV VGDIQESIHF IKYKRSENML YVFADDLAPR WMTSSVMLDY
     DTVAGADKFG NIFVLRLPLL ISDEVEEDPT GTKLKFESGT LNGAPHKLDH IANFFVGDTV
     TTLNKTSLVV GGPEVILYTT ISGAIGALIP FTSREDVDFF STLEMNMRSD CLPLCGRDHL
     AYRSYYFPVK NIIDGDLCEQ FSTLNYQKQL SISEELSRSP SEVIKKLEEI RSQKLL